A spark to the powder keg: Microneedle-based antitumor nanomedicine targeting reactive oxygen species accumulation for chemodynamic/photothermal/chemotherapy

Liao, Kaixin; Niu, Boyi; Dong, Hui; He, Luxuan; Zhou, Yao; Sun, Ying; Yang, Dan; Wu, Chuanbin; Pan, Xin; Quan, Guilan

doi:10.1016/j.jcis.2022.08.042

Cited by 16 publications

(10 citation statements)

References 53 publications

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“…Cu 2+ catalyzed H 2 O 2 to generate hydroxyl radicals through the Fenton reaction, and PDA can generate heat under 808 nm light, which plays a joint anti-tumor role. Liao et al 154 used mesoporous silica nanoparticles to adsorb doxorubicin and gallic acid iron complexes, coated them with PDA, and then encapsulated nanoparticles in microneedles to treat melanoma. Reactive oxygen species are produced through the mitochondrial damage mode of DOX, and the cyclic reaction of GA with Fe causes hydrogen peroxide to generate hydroxyl radicals, and the depletion of glutathione and photothermal effect of PDA simultaneously enhance the formation of ROS.…”

Section: Microneedle Delivery Of Chemodynamic Therapeutic Drugsmentioning

confidence: 99%

“…Chemodynamic therapy refers to use of hydrogen peroxide (H 2 O 2 ) endogenously expressed in the acidic tumor microenvironment to catalyze Fenton or Fenton-like reactions by metal ions such as Fe 2+ , Fe 3+ , Cu 2+ , Mn 2+ and Mn 3+ , to produce hydroxyl free radicals and superoxide free radical anions, thereby killing tumor cells. 153,154 Its therapeutic effect is limited by various factors in the tumor microenvironment, such as limited expression of H 2 O 2 , insufficient acidic pH, and overexpression of glutathione (GSH). Glutathione consumes ROS and inhibits ROS-based CDT.…”

Section: Applications Of Microneedles In the Delivery Of Anti-tumor D...mentioning

confidence: 99%

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Applications and prospects of microneedles in tumor drug delivery

Zhang,

Liu,

2024

J. Mater. Chem. B

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Section: Microneedle Delivery Of Chemodynamic Therapeutic Drugsmentioning

confidence: 99%

Section: Applications Of Microneedles In the Delivery Of Anti-tumor D...mentioning

confidence: 99%

Applications and prospects of microneedles in tumor drug delivery

Zhang,

Liu,

2024

J. Mater. Chem. B

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“…In 2022, Quan et al prepared a HA MN-mediated multifunctional nanotransdermal therapeutic platform (M@ DGP-HA MNs) for inducing tumor apoptosis by enhancing the accumulation of ROS through a combination of chemodynamic/PTT/chemotherapeutic (Figure 13). [131] The mesoporous silicon loaded with DOX and gallic acid-iron is coated with dopamine, MSN@DOX/GA-Fe/PDA (M@DGP). After the nanotherapeutic system reaches the tumor site through the skin, PDA mediated rapid increase in the local temperature of the tumor under the irradiation of light can not only directly thermal ablate the tumor but also enhance the efficiency of toxic hydroxyl radicals (•OH) generated by the Fenton reaction of Fe 2+ .…”

Section: Combination Therapymentioning

confidence: 99%

Advances in Natural Polymer‐Based Transdermal Drug Delivery Systems for Tumor Therapy

Han

Liu

et al. 2023

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As an alternative to traditional oral and intravenous injections with limited efficacy, transdermal drug delivery (TDD) has shown great promise in tumor treatment. Over the past decade, natural polymers have been designed into various nanocarriers due to their excellent biocompatibility, biodegradability, and easy availability, providing more options for TDD. In addition, surface functionalization modification of the rich functional groups of natural polymers, which in turn are developed into targeted and stimulus‐responsive functional materials, allows precise delivery of drugs to tumor sites and release of drugs in response to specific stimuli. It not only improves the treatment efficiency of tumor but also reduces the toxic and side effects to normal tissues. Therefore, the development of natural polymer‐based TDD (NPTDD) systems has great potential in tumor therapy. In this review, the mechanism of NPTDD systems such as penetration enhancers, nanoparticles, microneedles, hydrogels and nanofibers prepared from hyaluronic acid, chitosan, sodium alginate, cellulose, heparin and protein, and their applications in tumor therapy are overviewed. This review also outlines the future prospects and current challenges of NPTDD systems for local treatment tumors.

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“…The outermost polydopamine (PDA) layer gives M@DGP excellent PTT performance and GSH consumption capacity and improves the efficiency of the Fe‐catalyzed Fenton reaction. [ 113 ]…”

Section: Microneedles For Cancer Therapymentioning

confidence: 99%

Recent Advances in the Multifunctional Microneedles: From Design to Cancer Preventing, Diagnosis, and Treatment

Jiang

Chen

Wang

et al. 2023

Adv Materials Technologies

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Microneedles (MNs) have been widely applied in transdermal drug delivery owing to their minimal invasiveness, safety, stability, and ease of administration, which is a promising tool to transport large molecules such as DNA, proteins, and other drugs into the skin. In recent years, many researchers employ it to treat various diseases including cancer because MNs ensure the targeted release of the loaded drugs at a predetermined place and time. More importantly, MNs have been used for tumor prevention or accurate diagnosis at the early stages of the tumor by combining vaccines or sensor. In addition, they can greatly improve the antitumor effect when loaded with various therapeutic agents to achieve combination therapy. In this review, the latest progress of MNs used for application in cancer treatment is highlighted, especially in the design of multifunctional MNs for cancer prevention, diagnosis, and treatment. Ultimately, the challenges encountered by MNs in the cancer field are analyzed, as well as prospects for future directions are discussed.

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A spark to the powder keg: Microneedle-based antitumor nanomedicine targeting reactive oxygen species accumulation for chemodynamic/photothermal/chemotherapy

Cited by 16 publications

References 53 publications

Applications and prospects of microneedles in tumor drug delivery

Applications and prospects of microneedles in tumor drug delivery

Advances in Natural Polymer‐Based Transdermal Drug Delivery Systems for Tumor Therapy

Recent Advances in the Multifunctional Microneedles: From Design to Cancer Preventing, Diagnosis, and Treatment

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