A Spatial Distribution Analysis on the Deposition Mechanism Complexity of the Organic Material of Kidney Stone

Warty, Yuni; Haryanto, Freddy; Fitri, L A; Haekal, Mohammad; Herman, H.

doi:10.31661/jbpe.v0i0.1104

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…The common clinical complex renal stones are staghorn calculi and intrapelvic cast stones [ 20 ]. For single branch staghorn calculi of extrarenal renal pelvis or complete intrapelvic cast stones, laparoscopic pyelolithotomy can be performed successfully.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Laparoscopic Surgery and Traditional Open Surgery on Stone Clearance, Laboratory Indexes and Life Quality in Patients with Renal Calculi

Ai¹,

Dong²,

Li³

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. A case-control study was conducted to determine the effectiveness of laparoscopic surgery and traditional open surgery on stone clearance, laboratory indexes, and life quality in patients with renal calculi. Methods. During March 2017 to March 2022, 272 patients with complex renal calculi (CRC) cured in our hospital were assigned into control group ( n = 136 ) and research group ( n = 136 ) arbitrarily. The former accepted traditional open surgery, while the latter accepted laparoscopic surgery. The operation time, intraoperative blood loss, hospital stay, and time of getting out of bed were compared. The degree of postoperative incision pain was assessed by visual analogue scale (VAS). The life quality was assessed by the Comprehensive Assessment Questionnaire-74 (GQOL-74). The indexes of renal function and urine metabolism were measured. Then, the postoperative stone clearance rate and complications were calculated. Results. Operation time, blood loss intraoperatively, time out of bed, and hospitalization were all remarkably reduced in the research group, and the difference was statistically significant ( P < 0.05 ). The complete stone clearance rates in study and control cohorts were 75.73% and 63.24%, respectively. The VAS scores were lessened after the operation. Compared with the two groups, the VAS scores of the research group were remarkably lower at 1 to 2 weeks and 1 and 3 months after the operation, and the difference was statistically significant ( P < 0.05 ). One week after operation, the levels of β 2-microglobulin (β 2-MG), N-acetyl-β-glucosaminidase (NAG), and renal injury molecule-1 (kidney injury molecule-1, Kim-1) in the research group were remarkably lower. The levels of urinary β 2-MG, NAG, and KIM-1 in the research group were remarkably lower, and the difference was statistically significant ( P < 0.05 ). One week after operation, the levels of urinary oxalic acid, uric acid, and urinary calcium lessened averagely. The levels of urinary oxalic acid, uric acid, and urinary calcium in the research group were lower, and the difference was statistically significant ( P < 0.05 ). The quality-of-life scores were compared. One week after the operation, the scores of physical function, psychological function, social function, and material function were all augmented, and the difference was statistically significant ( P < 0.05 ). The incidence of complications was 9.56% and 2.21%, respectively. The incidence of complications in the research group was lower, and the difference was statistically significant ( P < 0.05 ). Conclusion. Laparoscopic surgery is successful when treating CRC, which is superior to invasive surgery in postoperative complications, stone clearance rate, improvement of postoperative renal function, and life quality. It is one of the ideal treatment methods for CRC. However, the role of open surgery when treating CRC cannot be ignored. This needs to be further confirmed by large samples of randomized controlled trials.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Laparoscopic Surgery and Traditional Open Surgery on Stone Clearance, Laboratory Indexes and Life Quality in Patients with Renal Calculi

Ai¹,

Dong²,

Li³

et al. 2022

Computational and Mathematical Methods in Medicine

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“…The FTIR of a calcium oxalate kidney stone ( Figure 4 D) shows three major peaks at 1611, 1313, and 778 cm –1 corresponding to C=O stretch, C–O stretch, and C–C stretch, respectively, and is consistent with the literature. 50 , 53 , 56 , 57 After photonic lithotripsy, the white surface was scraped for analysis and compared with standard calcium carbonate. The FTIR spectra clearly show three additional peaks at 1394, 872, and 712 cm –1 corresponding to calcium carbonate peaks.…”

Section: Mechanistic Insights For Photonic Lithotripsymentioning

confidence: 99%

Photonic Lithotripsy: Near-Infrared Laser Activated Nanomaterials for Kidney Stone Comminution

Houlihan

Kang

et al. 2023

Nano Lett.

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Near-infrared activated nanomaterials have been reported for biomedical applications ranging from photothermal tumor destruction to biofilm eradication and energy-gated drug delivery. However, the focus so far has been on soft tissues, and little is known about energy delivery to hard tissues, which have thousand-fold higher mechanical strength. We present photonic lithotripsy with carbon and gold nanomaterials for fragmenting human kidney stones. The efficacy of stone comminution is dependent on the size and photonic properties of the nanomaterials. Surface restructuring and decomposition of calcium oxalate to calcium carbonate support the contribution of photothermal energy to stone failure. Photonic lithotripsy has several advantages over current laser lithotripsy, including low operating power, noncontact laser operation (distances of at least 10 mm), and ability to break all common stones. Our observations can inspire the development of rapid, minimally invasive techniques for kidney stone treatment and extrapolate to other hard tissues such as enamel and bone.

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“…There are different types of minerals that can form urinary stones and Calcium Oxalate is the most common stone component [ 3 ]. Y Warty et al [ 4 ] analyzed the organic material and declared kidney stones have a different composition of elements in each layer.…”

Section: Introductionmentioning

confidence: 99%

Multiphysics Analysis of Ultrasonic Shock Wave Lithotripsy and Side Effects on Surrounding Tissues

2021

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Background: Today, the most common method for kidney stone therapy is extracorporeal shock wave lithotripsy. Current research is a numerical simulation of kidney stone fragmentation via ultrasonic shock waves. Most numerical studies in lithotripsy have been carried out using the elasticity or energy method and neglected the dissipation phenomenon. In the current study, it is solved by not only the linear acoustics equation, but also the Westervelt acoustics equation which nonlinearity and dissipation are involved.Objective: This study is to compare two methods for simulation of shock wave lithotripsy, clarifying the effect of shock wave profiles and stones' material, and investigating side effects on surrounding tissues.Material and Methods: Computational study is done using COMSOL Multiphysics, commercial software based on the finite element method. Nonlinear governing equations of acoustics, elasticity and bioheat-transfer are coupled and solved.Results: A decrease in the rise time of shock wave leads to increase the produced acoustic pressure and enlarge focus region. The shock wave damages kidney tissues in both linear and nonlinear simulation but the damage due to high temperature is very negligible compared to the High Intensity Focused Ultrasound (HIFU). Conclusion:Disaffiliation of wave nonlinearity causes a high incompatibility with reality. Stone's material is an important factor, affecting the fragmentation.

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A Spatial Distribution Analysis on the Deposition Mechanism Complexity of the Organic Material of Kidney Stone

Cited by 4 publications

References 25 publications

Comparison of the Effects of Laparoscopic Surgery and Traditional Open Surgery on Stone Clearance, Laboratory Indexes and Life Quality in Patients with Renal Calculi

Comparison of the Effects of Laparoscopic Surgery and Traditional Open Surgery on Stone Clearance, Laboratory Indexes and Life Quality in Patients with Renal Calculi

Photonic Lithotripsy: Near-Infrared Laser Activated Nanomaterials for Kidney Stone Comminution

Multiphysics Analysis of Ultrasonic Shock Wave Lithotripsy and Side Effects on Surrounding Tissues

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