2003
DOI: 10.1016/s0022-2836(03)00437-6
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A Spatially Extended Stochastic Model of the Bacterial Chemotaxis Signalling Pathway

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Cited by 130 publications
(120 citation statements)
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“…Methylation and demethylation are complex biochemical processes that involve the enhanced recruitment of CheR and CheB to the receptors by a tethering site that is distinct from methylation sites (14,15). As in previous models of chemotaxis (7,(16)(17)(18)(19)(20)(21)(22)(23), we coarse-grain the underlying biochemical details to capture the behavior of the full chemotaxis system obtained from experiments on living cells. In particular, we assume that receptor-kinase complexes can be either active or inactive (23), and we use the Barkai and Leibler activity-dependent feedback in the receptor modification system that yields robust exact adaptation (7,8) (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…Methylation and demethylation are complex biochemical processes that involve the enhanced recruitment of CheR and CheB to the receptors by a tethering site that is distinct from methylation sites (14,15). As in previous models of chemotaxis (7,(16)(17)(18)(19)(20)(21)(22)(23), we coarse-grain the underlying biochemical details to capture the behavior of the full chemotaxis system obtained from experiments on living cells. In particular, we assume that receptor-kinase complexes can be either active or inactive (23), and we use the Barkai and Leibler activity-dependent feedback in the receptor modification system that yields robust exact adaptation (7,8) (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…We use Michaelis-Menten kinetics for the methylation-demethylation steps of the complexes. Here, CheR (CheB-P) binds the methylation sites only of inactive (active) receptors (16)(17)(18)(19)(20)(21)(22)(23). But in Sect.…”
Section: Resultsmentioning
confidence: 99%
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“…In addition to MWC models, Ising-type lattice models with relatively weak couplings have been used to explain receptor cooperativity (38,39). Ising models with trimers as subunits can explain receptor-specific methylation and high sensitivity of the wild-type response, but cannot explain the high sensitivity of the cheR mutant (A ≪ 1), as cooperativity in these models is only high near A ≈ 0.5 (27).…”
Section: Discussionmentioning
confidence: 99%
“…For low Reynolds number, viscous environments chemotaxis in organisms such as Escherichia coli has been studied extensively in the context of chemical signalling pathways (11,12), the fluid mechanics of locomotion (13), and optimal strategies (14). However, when chemoattractants are advected by stochastically fluctuating, chaotic flows, the mechanisms that allow organisms to respond effectively to these signals are poorly understood.…”
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confidence: 99%