A Spatiotemporal Analysis of Organ‐Specific Lupus Flares in Relation to Atmospheric Variables and Fine Particulate Matter Pollution

Stojan, George; Kvit, Anton; Curriero, Frank C.; Petri, Michelle

doi:10.1002/art.41217

Cited by 26 publications

(14 citation statements)

References 24 publications

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“…Finally, 12 articles were eligible for this review. 7,[14][15][16][17][18][19][20][21][22][23][24] In Figure 1, (a) PRISMA flow chart depicts the whole assessment process.…”

Section: Selection Process Resultsmentioning

confidence: 99%

The effect of air pollution on systemic lupus erythematosus: A systematic review and meta-analysis

Rezayat

Jafari

Nourbakhsh

et al. 2022

Lupus

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Background Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from impaired inflammatory responses. Given the role of air pollution on increasing inflammatory mediators, thus, we aimed to systematically review and meta-analyze evidence regarding an association between short-term exposure to air pollution and SLE onset, activity, and hospitalization. Methods Electronic databases including Web of Science, PubMed, Scopus, and Embase were searched for all published articles until July 5, 2021. Newcastle Ottawa Scale (NOS) checklist was used to assess the quality of individual studies. Relevant demographic data and the intended results of the selected studies were extracted, and their adjusted risk ratios (RRs) were pooled using random and fixed effect analysis based on the heterogeneity index. Findings Twelve studies were entered in our systematic review, and finally, six publications were enrolled in meta-analysis. Overall, Meta-analysis showed no significant association between an increase of PM2.5 on the third day and SLEDAI score with pooled adjusted RR of 1.212 (95% CI, 0,853–1.721), p-value = 0.284. However, there was a positive relationship between 6 days increase of Particulate matter (PM) 2.5 and the systemic lupus erythematosus disease activity Index (SLEDAI) score (pooled adjusted RR 1.112; 95% CI, 1.005–1.231), p-value = 0.040. There was no significant association between carbon monoxide (CO), nitrogen dioxide (NO2), PM2.5, and PM10 increase in the air and hospitalization of SLE patients with pooled RR of 1.021 (95% CI, 0,986–1.1.057), p-value = 0.249, 1.034 (95% CI, 0.996–1.068); p-value = 0.079, 1.042 (95% CI, 0.994–1.092); p-value = 0.084 and 1.004 (95% CI, 0.996–1.013); p-value = 0.323, respectively. Also, analysis showed a significant relation between ozone (O3) increase and hospitalization with a pooled RR of 1.076 (95% CI, 1.009–1.147); p-value = 0.025. Finally, analysis of SO2 increase and risk of hospitalization demonstrated no significant relationship with the pooled RR of 1.011; (95% CI, 0.962–1.062), p-value = 0.0.671. Conclusion Our findings prove that PM2.5 was associated with increased SLE risk. We also showed that only O3 was associated with increased hospital admissions of SLE patients.

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“…Finally, 12 articles were eligible for this review. 7,[14][15][16][17][18][19][20][21][22][23][24] In Figure 1, (a) PRISMA flow chart depicts the whole assessment process.…”

Section: Selection Process Resultsmentioning

confidence: 99%

The effect of air pollution on systemic lupus erythematosus: A systematic review and meta-analysis

Rezayat

Jafari

Nourbakhsh

et al. 2022

Lupus

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“…Many of these have clear links to aspects of immunity relevant to disease pathogenesis, such as type 1 interferon production, clearance of self‐antigens and the complement pathway. Environmental risk factors implicated in SLE include ultraviolet radiation exposure, smoking, viral infections, low vitamin D and particulate air pollutants 11,12 . A reversible lupus syndrome is also associated with numerous drugs, including tumour necrosis factor inhibitors, isoniazid, hydralazine and minocycline.…”

Section: Pathogenesismentioning

confidence: 99%

“…Environmental risk factors implicated in SLE include ultraviolet radiation exposure, smoking, viral infections, low vitamin D and particulate air pollutants. 11,12 A reversible lupus syndrome is also associated with numerous drugs, including tumour necrosis factor inhibitors, isoniazid, hydralazine and minocycline. The precise interactions between different risk factors are complex and their exact roles in disease development are not well understood, particularly when applied at an individual patient level.…”

Section: Genetic and Environmental Risk Factorsmentioning

confidence: 99%

Systemic lupus erythematosus: a clinical update

Connelly

Morand

2021

Internal Medicine Journal

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Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease known for its complexity and heterogeneity. Striking diversity can be observed between individual patients, in terms of clinical manifestations, serological abnormalities, disease progression and response to therapy. Furthermore, dysfunction of a broad range of immune pathways underlies disease development and expression. An appreciation of this diversity is vital in order to diagnose accurately and appropriately treat patients with SLE as there is no one-size-fits-all diagnostic test or treatment. Optimal management involves identifying affected organs, assessing severity, differentiating activity from irreversible damage and tailoring immunosuppressive treatment accordingly. Non-pharmacological interventions, attention to disease and treatment-related comorbidities and addressing the significant impact on health-related quality of life are also crucial to maximising patient outcomes.

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“…The Space-time Scan Statistic is implemented in the freely available software called SaTScan ™ [26]. It has been widely used in environmental studies such as clusters detection of forest fire events [27][28][29], and pollution [30]. It has the additional advantage of detecting the cluster's location and time-frame, while also evaluating its statistical significance as recommended for environmental studies by Tonini et al [31] and Tuia et al [32].…”

Section: Introductionmentioning

confidence: 99%

Space-time Cluster Analysis of Accidental Oil Spills in Rivers State, Nigeria, 2011-2019

Ullah¹,

Daud²,

Zainuddin³

et al. 2021

Computers, Materials &Amp; Continua

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Oil spills cause environmental pollution with a serious threat to local communities and sustainable development. Accidental oil spills can be modelled as a stochastic process where each oil spill event is described by its spatial locations and incidence-time and hence allow for space-time cluster analysis. Spacetime cluster analysis can detect space-time pattern distribution of oil spills which can be useful for implementing preventive measures and evidence-based decision making. This study aims to detect the space-time clusters of accidental oil spills in Rivers state, Nigeria through the Space-time Scan Statistic. The Space-time Scan Statistic was applied under the permutation model to the oil spill data (each for sabotage and operational oil spills) collected at Local Government Area (LGA)-level during the period from 2011 to 2019. The results show that the sabotage oil spill clusters have covered most of the LGAs in the southern part of the state at the start of the study period and then in 2018-2019, it moved to the west covering a single LGA. The operational oil spill clusters covered two neighboringLGAs in the south. In addition, the temporal cluster of sabotage oil spills was seen in 2019 and operational oil spills in 2011-2012. The sabotage oil spills show an increasing trend with the maximum in 2019 while the operational oil spills show a decreasing trend with the minimum in 2019. These findings assist in more effective decision-making for combating the environmental problems and controlling the future spill incidence in the cluster-regions.

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A Spatiotemporal Analysis of Organ‐Specific Lupus Flares in Relation to Atmospheric Variables and Fine Particulate Matter Pollution

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 26 publications

References 24 publications

The effect of air pollution on systemic lupus erythematosus: A systematic review and meta-analysis

The effect of air pollution on systemic lupus erythematosus: A systematic review and meta-analysis

Systemic lupus erythematosus: a clinical update

Space-time Cluster Analysis of Accidental Oil Spills in Rivers State, Nigeria, 2011-2019

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