A specific conformation of the territory of chromosome 17 locates ERBB - 2 sequences to a DNase-hypersensitive domain at the nuclear periphery

Park, Paul C.; Boni, U. De

doi:10.1007/s004120050284

Cited by 36 publications

(16 citation statements)

References 41 publications

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“…In contrast, the gene-poor region and the centromere never appeared on a large external chromatin loop. Similar thin chromatin protrusions carrying the amplified and highly expressed ERBB2 gene have also been observed extending from the chromosome 17 territories in a breast cancer cell line (Park and de Boni, 1998). Furthermore, in a study on terminally differentiated human bronchial cells, comparison of the two homologues of each of the autosomes showed one of the two generally to have a more "open" configuration than the other, displaying fiber shaped extensions (Koss, 1998).…”

Section: Transcription and The Territorymentioning

confidence: 73%

Mini review: Form and function in the human interphase chromosome

Chevret¹,

Volpi²,

Sheer³

2000

Cytogenet Genome Res

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A key feature of interphase chromosomes is their compaction into discrete “territories” in the nucleus. In this review, we focus on the compartmentalization of the genome conferred by this organization and evaluate our current understanding of the role of large-scale chromatin folding in the regulation of gene expression. We examine evidence for the hypothesis that transcription occurs at the external surfaces of chromosomes and follow its evolution to include transcription at the surfaces of chromatin-rich domains within chromosomes. We also present prevailing views regarding the details of large-scale chromatin folding and the functional relationship between chromatin and the enigmatic nuclear matrix.

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Section: Transcription and The Territorymentioning

confidence: 73%

Mini review: Form and function in the human interphase chromosome

Chevret¹,

Volpi²,

Sheer³

2000

Cytogenet Genome Res

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“…However, another possible feature of chromosomal evolution is the consequences of changes in the structure of the karyotype on genome function (Capanna and Redi 1994). The nuclear organization of chromosomes is known to be spatially nonrandom and gene expression has been shown to be related to chromosomal position (HeslopHarisson and Bennet 1990;Milot et al 1996;Marshall et al 1997;Park and De Boni 1998). Thus, structural rearrangements which modify the topology of interphasic chromosomes within the nucleus may lead to alterations of genome activity and contribute to reduce the fitness of the carriers (Capanna and Redi 1994;Qumsiyeh 1995).…”

mentioning

confidence: 99%

Developmental Instability in Wild Chromosomal Hybrids of the House Mouse

et al. 1999

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Abstract.-In wild populations of the house mouse from Tunisia, fluctuating asymmetry and character size of tooth traits were compared between chromosomal races (2n = 40, all acrocentric standard karyotype, and 2n = 22, with nine fixed Robertsonian fusions) and their natural hybrids. Developmental stability was impaired in hybrids compared to both parental groups. Because genetic divergence measured by allozyme markers was low, genomic incompatibilities were not expected between the chromosomal races. This suggests that differentiation of gene systems specifically involved in development may have occurred between the chromosomal races. Support for the latter was found in the study of character size which showed that the 2n = 22 mice had smaller teeth than either the hybrid or the standard mice. The study of Tunisian chromosomal races thus shows that chromosomal evolution may lead to important changes in coadapted gene systems without involving extensive genic differentiation.

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“…SCDs with active transcription (R-bands and T-bands) organize internal nuclear compartments for gene transcription [82]. As an example, the gene ERBB-2 is localized on the surface of the chromosome 17 domain in interphase nuclei in a DNase-hypersensitive domain facing the nuclear periphery [83]. The data support the concept that chromosomes and SCDs build unique spatial relationships with other SCDs when constructing the nucleus at telophase (see fig.…”

Section: Functional Subchromosomal Domains In Interphase Related To Tmentioning

confidence: 67%

Structure and function of the nucleus: anatomy and physiology of chromatin

Qumsiyeh¹

1999

CMLS, Cell. Mol. Life Sci.

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A review of the literature accumulated recently on nuclear structure and function reveals that: (1) The nucleus is the interphase form of chromosomes (chromatin organizes and compartmentalizes the nucleus). (2) These organizational programs are morphogenetic in nature and are regulated by both DNA content and by epigenetic interactions. (3) In mammals with a diploid complement, it is very likely that chromosomes construct interphase domains based on their structural milieu (including any imprinted areas). These are the same structured areas that correspond to G- and R-bands with their varying DNA content and early versus late replication. (4) Changes in a position of a segment of DNA from one chromatin environment to another changes its availability to early replication factors and transcription factors as well as its nuclear positioning and chromatin architecture. This process was first described as positional effect variegation in Drosophila but is now found to be more general and explains many cases of direct clinical relevance. Examples in mammals include spreading of X inactivation, imprinting and changes in chromatin associated with chromosome translocation. (5) Chromosomal autoconstruction and reconstruction into a functional nucleus are altered during cell cycle and during differentiation (much more work needed on this area).

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A specific conformation of the territory of chromosome 17 locates ERBB - 2 sequences to a DNase-hypersensitive domain at the nuclear periphery

Cited by 36 publications

References 41 publications

Mini review: Form and function in the human interphase chromosome

Mini review: Form and function in the human interphase chromosome

Developmental Instability in Wild Chromosomal Hybrids of the House Mouse

Structure and function of the nucleus: anatomy and physiology of chromatin

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