A Specific Drug Delivery System for Targeted Accumulation and Tissue Penetration in Prostate Tumors Based on Microbially Synthesized PHBHHx Biopolyester and iRGD Peptide Fused PhaP

Fan, Fan; Wu, Xueyuan; Zhao, Jiping; Ran, Ganqiao; Shang, Sen; Li, Mingchuan; Lu, Xiaoyun

doi:10.1021/acsabm.8b00524

Cited by 13 publications

(7 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another advantage is that some specific PNs can be designed and custom-made by genetic engineering and microbial synthesis, such as the drug nanocarriers for targeted accumulation and tissue penetration in prostate tumors. 147 However, the consumer acceptance and large-scale economic production may be the restriction factors of microbial protein. As previously mentioned, silk protein can be used to encapsulate, protect, and deliver biologically active substances.…”

Section: Nanocarriersmentioning

confidence: 99%

Advances in Protein-Based Nanocarriers of Bioactive Compounds: From Microscopic Molecular Principles to Macroscopical Structural and Functional Attributes

Zhang

Han

Xie

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Many proteins can be used to fabricate nanocarriers for encapsulation, protection, and controlled release of nutraceuticals. This review examined the protein-based nanocarriers from microscopic molecular characteristics to the macroscopical structural and functional attributes. Structural, physical, and chemical properties of protein-based nanocarriers were introduced in detail. The spatial size, shape, water dispersibility, colloidal stability, etc. of protein-based nanocarriers were largely determined by the molecular physicochemical principles of protein. Different preparative techniques, including antisolvent precipitation, pH-driven, electrospray, and gelation methods, among others, can be used to fabricate different protein-based nanocarriers. Various modifications based on physical, chemical, and enzymatic approaches can be used to improve the functional performance of these nanocarriers. Protein is a natural resource with a wide range of sources, including plant, animal, and microbial, which are usually used to fabricate the nanocarriers. Protein-based nanocarriers have many advantages in aid of the application of bioactive ingredients to the medical, food, and cosmetic industries.

show abstract

Section: Nanocarriersmentioning

confidence: 99%

Advances in Protein-Based Nanocarriers of Bioactive Compounds: From Microscopic Molecular Principles to Macroscopical Structural and Functional Attributes

Zhang

Han

Xie

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Human prostate cancer cell line PC3 and human colon cancer cell lines HCT116 and SW620 were purchased from Chinese Academy of Sciences Cell Bank (Shanghai, CHN), and cultured according to routine procedures. , Specific pathogen free (SPF) BALB/c normal and nude mice (male, 20 ± 1 g) were supplied and bred by the Experimental Animal Center, School of Medicine, Xi’an Jiaotong University (Shaanxi, CHN) in a strict clean environment. All animal experiments were in line with the license (No.…”

Section: Methodsmentioning

confidence: 99%

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Biopolyester Based Nanoparticles as NVP-BEZ235 Delivery Vehicle for Tumor Targeting Therapy

et al. 2019

Self Cite

View full text Add to dashboard Cite

As a biopolyester with excellent properties, the potential biomedical applications of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) have gained extensive attention. In this research, PHBHHx was fabricated into nanoparticles (NPs) to encapsulate NVP-BEZ235 (BEZ), an efficient kinase inhibitor/antitumor agent, for tumor targeting therapy. The resulting BEZ-NPs displayed a regularly spherical form with an appropriate diameter at 76.0 ± 3.6 nm. The encapsulation efficiency of BEZ was 83.7 ± 3.6%, and the sustained release profiles showed that almost 97% of BEZ could be gradually unrestricted from PHBHHx NPs within 72 h. The nanotoxicity studies revealed a satisfactory biosafety of PHBHHx NPs. PHBHHx NPs presented significantly improved cellular uptake in human prostate cancer cell line PC3, thereby enhancing the antiproliferation ability and kinase inhibitory activity of BEZ in vitro. More importantly, the in vivo real-time imaging demonstrated the adequate tumor targeting and accumulation capability of PHBHHx NPs. The remarkably delayed tumor growth, increased tumor necrosis, and reduced tumor proliferation in PC3 tumor xenograft mice further confirmed the antitumor efficacies of BEZ-loaded PHBHHx NPs. The above results suggest that PHBHHx NPs might be a promising drug delivery vehicle, safe and effective, for tumor targeting therapy.

show abstract

“…PHA are popular in delivery carrier designs on account of their biodegradability, biocompatibility, and excellent physicochemical and mechanical properties. Today, PHA‐based polymers have been widely used in nanomedicine, food packaging, and wound dressing …”

Section: Biomedicine Application Of Pha Copolymermentioning

confidence: 99%

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Luo

Liu

et al. 2019

Biotechnology Journal

View full text Add to dashboard Cite

In recent years, naturally biodegradable polyhydroxyalkanoate (PHA) monopolymers have become focus of public attentions due to their good biocompatibility. However, due to its poor mechanical properties, high production costs, and limited functionality, its applications in materials, energy, and biomedical applications are greatly limited. In recent years, researchers have found that PHA copolymers have better thermal properties, mechanical processability, and physicochemical properties relative to their homopolymers. This review summarizes the synthesis of PHA copolymers by the latest biosynthetic and chemical modification methods. The modified PHA copolymer could greatly reduce the production cost with elevated mechanical or physicochemical properties, which can further meet the practical needs of various fields. This review further summarizes the broad applications of modified PHA copolymers in biomedical applications, which might shred lights on their commercial applications.

show abstract

A Specific Drug Delivery System for Targeted Accumulation and Tissue Penetration in Prostate Tumors Based on Microbially Synthesized PHBHHx Biopolyester and iRGD Peptide Fused PhaP

Cited by 13 publications

References 59 publications

Advances in Protein-Based Nanocarriers of Bioactive Compounds: From Microscopic Molecular Principles to Macroscopical Structural and Functional Attributes

Advances in Protein-Based Nanocarriers of Bioactive Compounds: From Microscopic Molecular Principles to Macroscopical Structural and Functional Attributes

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Biopolyester Based Nanoparticles as NVP-BEZ235 Delivery Vehicle for Tumor Targeting Therapy

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Contact Info

Product

Resources

About