A Specific Feedback by Anti-IgE Autoantibodies on the Cytokine Network in Allergy

IgG Anti-IgE Autoantibodies in Visceral Leishmaniasis

“…According to previous hypothesis IgG anti-IgE autoantibodies may exert the role of specific feed back molecules that neutralize the IgE immune response induced by the cytokine network (Stadler et al 1993a). IgG anti-IgE autoantibodies are a heterogeneous population of antibodies that execute functions of physiological control of the specific IgE Th2 immune response, as inhibition of IgE synthesis and removal of IgE from CD23 receptor (Stadler et al 1993b). In atopic diseases as asthma these autoantibodies have been implicated in the modulation of the IgE immune response, mainly because they may react with epitopes located in C epsilon 2 domain of IgE, which is involved in the binding of this immunoglobulin on Fcε high affinity receptor (FcεRI) on the surface of basophils and mast cells, preventing the sensitization of these cells (Shakib & Powell-Richards 1991, Stadler et al 1995.…”