A Specific Interferon (IFN)-stimulated Response Element of the Distal HLA-G Promoter Binds IFN-regulatory Factor 1 and Mediates Enhancement of This Nonclassical Class I Gene by IFN-β

Transplacental Infection of HIV-1 and the Associated Risk Factors In Utero

“…Some authors have commented that HLA-G expression occurs in a complex manner by several cytokines. It has also been reported that HLA-G expression has been up regulated with cytomegaly virus and HIV [39][40][41]. In agreement with these earlier comments this study reports an up-regulation of HLA-G 1 HIV-1 infected placental tissue.…”

HLA-G Transactivation by cAMP-response Element-binding Protein (CREB)

“…D, transient transfection of HLA-G reporter constructs bearing mutations in CRE Ϫ1380 (pGL3-Gm1), CRE Ϫ930 (pGL3-Gm2), or CRE Ϫ770 (pGL3-Gm3) or in all three CRE/TRE sites (pGL3-Gm1-2-3) with CREB expression vector ( There is still much debate as to whether HLA-G is responsive to IFN. Previous reports have indicated that HLA-G is weakly induced by IFN␥ and IFN␤ (25). In this study, we identified one putative ISRE and two putative GAS sites.…”

Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA‐G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients

“…Given that the 5A6G7 mAb recognizes both HLA-G5 and -G6 soluble isoforms, we cannot exclude that, in addition to HLA-G5, HLA-G6 may also be expressed in our experiments. It is known that the production of HLA-G depends on various factors such as cytokines (IL-10, IFN- § , g , + ) [30,31], stress [32], or chemical agents (corticoids, demethylating agents) [33,34]. However, it also has to be noted that the induction of HLA-G1 and/or HLA-G5 expression by responder T cells from a given donor is influenced by the allogeneic stimulator cell population.…”