A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory

Altinbilek, B.; Manahan‐Vaughan, Denise

doi:10.1016/j.neuroscience.2008.07.045

Cited by 38 publications

(30 citation statements)

References 73 publications

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“…Prolonged antagonism of mGluR II results in the appearance of spatial memory deficits (Altinbilek and Manahan-Vaughan 2009) demonstrating that mGluR II are involved in modulating memory. We have demonstrated that presynaptic stimulation at 5 Hz within the theta frequency (4--12 Hz) induces depression of glutamatergic transmission via activation of mGluR II.…”

Section: Discussionmentioning

confidence: 99%

Activation of Group II Metabotropic Glutamate Receptors Inhibits Glutamatergic Transmission in the Rat Entorhinal Cortex via Reduction of Glutamate Release Probability

et al. 2011

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Glutamate interacts with ionotropic and metabotropic glutamate receptors (mGluRs). Whereas the entorhinal cortex (EC) is a principal structure involved in learning and memory, the roles of mGluRs in synaptic transmission in the EC have not been completely determined. Here, we show that activation of group II mGluRs (mGluR II) induced robust depression of glutamatergic transmission in the EC. The mGluR II--induced depression was due to a selective reduction of presynaptic release probability without alterations of the quantal size and the number of release sites. The mechanisms underlying mGluR II--mediated suppression of glutamate release included the inhibition of presynaptic release machinery and the depression of presynaptic P/Q-type Ca 21 channels. Whereas mGluR II--induced depression required the function of Ga i/o proteins, protein kinase A (PKA) pathway was only involved in mGluR II--mediated inhibition of release machinery and thereby partially required for mGluR II--induced inhibition of glutamate release. Presynaptic stimulation at 5 Hz for 10 min also induced depression of glutamatergic transmission via activation of presynaptic mGluR II suggesting an endogenous role for mGluR II in modulating glutamatergic transmission.

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Section: Discussionmentioning

confidence: 99%

Activation of Group II Metabotropic Glutamate Receptors Inhibits Glutamatergic Transmission in the Rat Entorhinal Cortex via Reduction of Glutamate Release Probability

et al. 2011

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“…A major function of presynaptic mGlu2/3 receptor is to inhibit neurotransmitter release. Both receptors have an established role in the regulation of synaptic plasticity, particularly in the induction of LTD of excitatory synaptic transmission (Yokoi et al, 1996; Manahan-Vaughan, 1998; Kahn et al, 2001; Kilbride et al, 2001; Renger et al, 2002; Robbe et al, 2002; Grueter and Winder, 2005; Nicholls et al, 2006; Altinbilek and Manahan-Vaughan, 2009). …”

Section: Detailed Description Of Mglu Receptor Subtypesmentioning

confidence: 99%

Metabotropic glutamate receptors: From the workbench to the bedside

et al. 2011

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Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 articles have been published since then, and subtype-selective mGlu receptor ligands are now under clinical development for the treatment of a variety of disorders such as Fragile-X syndrome, schizophrenia, Parkinson’s disease and L-DOPA-induced dyskinesias, generalized anxiety disorder, chronic pain, and gastroesophageal reflux disorder. Prof. Erminio Costa was linked to the early times of the mGlu receptor history, when a few research groups challenged the general belief that glutamate could only activate ionotropic receptors and all metabolic responses to glutamate were secondary to calcium entry. This review moves from those nostalgic times to the most recent advances in the physiology and pharmacology of mGlu receptors, and highlights the role of individual mGlu receptor subtypes in the pathophysiology of human disorders. This article is part of a Special Issue entitled ‘Trends in Neuropharmacology: In Memory of Erminio Costa’.

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“…LTD can be induced by applying group 1 specific agonists such as 3,5-dihydroxyphenylglycine (DHPG; Palmer et al, 1997). In the context of this review, we will focus on this group even if antagonism of pre-synaptic group 2 mGluRs can modulate LTD and spatial memory (Altinbilek and Manahan-Vaughan, 2009). …”

Section: Group 1 Metabotropic Glutamate Receptors and Successful Agingmentioning

confidence: 99%

Group 1 Metabotropic Glutamate Receptor Function and Its Regulation of Learning and Memory in the Aging Brain

Ménard¹,

Quirion²

2012

Front. Pharmacol.

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Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon. The excitatory neurotransmitter glutamate and its receptors have been closely linked to spatial learning and hippocampus-dependent memory processes. For decades, ionotropic glutamate receptors have been known to play a critical role in synaptic plasticity, a form of adaptation regulating memory formation. Over the past 10 years, several groups have shown the importance of group 1 metabotropic glutamate receptor (mGluR) in successful cognitive aging. These G-protein-coupled receptors are enriched in the hippocampal formation and interact physically with other proteins in the membrane including glutamate ionotropic receptors. Synaptic plasticity is crucial to maintain cognitive abilities and long-term depression (LTD) induced by group 1 mGluR activation, which has been linked to memory in the aging brain. The translation and synthesis of proteins by mGluR-LTD modulate ionotropic receptor trafficking and expression of immediate early genes related to cognition. Fragile X syndrome, a genetic form of autism characterized by memory deficits, has been associated to mGluR receptor malfunction and aberrant activation of its downstream signaling pathways. Dysfunction of mGluR could also be involved in neurodegenerative disorders like Alzheimer’s disease (AD). Indeed, beta-amyloid, the main component of insoluble senile plaques and one of the hallmarks of AD, occludes mGluR-dependent LTD leading to diminished functional synapses. This review highlights recent findings regarding mGluR signaling, related synaptic plasticity, and their potential involvement in normal aging and neurological disorders.

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A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory

Cited by 38 publications

References 73 publications

Activation of Group II Metabotropic Glutamate Receptors Inhibits Glutamatergic Transmission in the Rat Entorhinal Cortex via Reduction of Glutamate Release Probability

Activation of Group II Metabotropic Glutamate Receptors Inhibits Glutamatergic Transmission in the Rat Entorhinal Cortex via Reduction of Glutamate Release Probability

Metabotropic glutamate receptors: From the workbench to the bedside

Group 1 Metabotropic Glutamate Receptor Function and Its Regulation of Learning and Memory in the Aging Brain

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