A specific role for the TFIID subunit TAF4 and RanBPM in neural progenitor differentiation

RanBPM, a novel interaction partner of the brain‐specific protein p42IP4/centaurin α‐1

“…Based on the ubiquitous expression, subcellular distribution and the existence of a large RanBPM complex it is not surprising that several Ran-BPM-interacting proteins have been described, including USP11 (Ideguchi et al 2002), the MET receptor (Wang et al 2002a), androgen and glucocorticoid receptor (Rao et al 2002), the integrin LFA-1 (Denti et al 2004), and p73 (Kramer et al 2005). In the neuronal context, also several interaction partners have been identified, such as Calbindin D 28K (Lutz et al 2003), neurotrophin receptors (Bai et al 2003;Yuan et al 2006), neuronal cell adhesion molecule L1 (Cheng et al 2005), ecto-nucleotidase CD39 (Wu et al 2006), the TFIID subunit TAF4 (Brunkhorst et al 2005) and plexin-A receptor (Togashi et al 2006). Within the cell they have different localization, some are nuclear proteins, others are cytosolic or membrane proteins.…”

“…For RanBPM, it has been reported that it can interact with the neuronal cell adhesion molecule L1 and thus modulates the activation of mitogen-activated protein kinase and regulates dendritic outgrowth (Cheng et al 2005). RanBPM can also interact with the transcription activation factor 4 (TAF4) and both regulate dendritic outgrowth (Brunkhorst et al 2005). RanBPM interacts with four isoforms of the plexin-A receptors, which are receptors for the axonal guidance molecule Sema3.…”

“…Consequently, different signaling cascades have to be activated. RanBPM could be a link to either the ERK mitogen-activated protein kinase pathway (Wang et al 2002a) or to the activation of nuclear transcription factors such as TAF4 (Brunkhorst et al 2005). Ligands of p42 IP4 such as the membrane lipid PtdIns(3,4,5)P 3 and soluble Ins(1,3,4,5)P 4 could work as a switch to turn on or turn off the different signaling pathways by determining the composition of the RanBPM/ p42 IP4 complexes in different cellular compartments.…”

Insulin signalling in mushroom body neurons regulates feeding behaviour inDrosophilalarvae

“…RanBPM has been implicated in various signalling pathways as a putative scaffolding protein (e.g. Bai et al, 2003;Mikolajczyk et al, 2003;Menon et al, 2004;Brunkhorst et al, 2005;Hafizi et al, 2005;Haase et al, 2008;Atabakhsh et al, 2009;Gong et al, 2009;Kim et al, 2009;Chang et al, 2010) (reviewed by Murrin and Talbot, 2007). RanBPM expression in PC12 cells promotes TrkB-dependent activation of the serine-threonine kinase Akt, a target of insulin signalling (Yin et al, 2010).…”

RanBPM regulates Zta-mediated transcriptional activity in Epstein–Barr virus

“…Rta also interacts with Zta if the expression of RanBPM was inhibited by RanBPM shRNA, which can be attributed to the fact that MCAF1 is capable of mediating Rta-Zta interaction (data not shown). Earlier studies have shown that RanBPM is a binding partner of the TFIID subunit, TAF4 (Brunkhorst et al, 2005), and we previously found that Rta also interacts with TAF4 to enhance Rta transactivation capability ; therefore, TAF4 may well play a role in RanBPM-mediated Rta-Zta synergy.…”