A specific role of magnetic isotopes in biological and ecological systems. Physics and biophysics beyond

Бучаченко, А. Л.; Bukhvostov, Alexander A.; Ermakov, Kirill V.; Kuznetsov, Dmitry A.

doi:10.1016/j.pbiomolbio.2020.02.007

Cited by 27 publications

(7 citation statements)

References 103 publications

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“…Since then, the term 'magnetic isotope effect' was dubbed for such phenomena as they are controlled by electronnuclear hyperfine coupling in the paramagnetic species. Moreover, isotope effects have been observed for a great variety of chemical and biochemical reactions involving oxygen, silicon, sulfur, germanium, tin, mercury, magnesium, calcium, zinc and uranium [65, 367,368,[375][376][377][378][379][380][381]. In this review, we focus on isotope effects from a spin perspective, see table 7.…”

Section: Drosophila-amnesiamentioning

confidence: 99%

Magnetic field effects in biology from the perspective of the radical pair mechanism

Zadeh-Haghighi

Simon

2022

J. R. Soc. Interface.

104

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Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, the magnetic energies implicated in these effects are much smaller than thermal energies. Here, we review these observations, and we suggest an explanation based on the radical pair mechanism, which involves the quantum dynamics of the electron and nuclear spins of transient radical molecules. While the radical pair mechanism has been studied in detail in the context of avian magnetoreception, the studies reviewed here show that magnetosensitivity is widespread throughout biology. We review magnetic field effects on various physiological functions, discussing static, hypomagnetic and oscillating magnetic fields, as well as isotope effects. We then review the radical pair mechanism as a potential unifying model for the described magnetic field effects, and we discuss plausible candidate molecules for the radical pairs. We review recent studies proposing that the radical pair mechanism provides explanations for isotope effects in xenon anaesthesia and lithium treatment of hyperactivity, magnetic field effects on the circadian clock, and hypomagnetic field effects on neurogenesis and microtubule assembly. We conclude by discussing future lines of investigation in this exciting new area of quantum biology.

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Section: Drosophila-amnesiamentioning

confidence: 99%

Magnetic field effects in biology from the perspective of the radical pair mechanism

Zadeh-Haghighi

Simon

2022

J. R. Soc. Interface.

104

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“…Since then, the term "magnetic isotope effect" was dubbed for such phenomena as they are controlled by electron-nuclear hyperfine coupling in the paramagnetic species. Moreover, isotope effects have been observed for a great variety of chemical and biochemical reactions involving oxygen, silicon, sulfur, germanium, tin, mercury, magnesium, calcium, zinc, and uranium 62,364,365,[372][373][374][375][376][377][378] . In this review, we focus on isotope effects from spin perspective, see Table 7.…”

Section: Medium/high-frequencymentioning

confidence: 99%

Magnetic field effects in biology from the perspective of the radical pair mechanism

Zadeh-Haghighi¹,

Simon²

2022

Preprint

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A large and growing body of research shows that weak magnetic fields can significantly influence various biological systems, including plants, animals, and humans. However, the underlying mechanisms behind these phenomena remain elusive. It is remarkable that the magnetic energies implicated in these effects are much smaller than thermal energies. Here we review these observations, of which there are now hundreds, and we suggest that a viable explanation is provided by the radical pair mechanism, which involves the quantum dynamics of the electron and nuclear spins of naturally occurring transient radical molecules. While the radical pair mechanism has been studied in detail in the context of avian magnetoreception, the studies reviewed here show that magnetosensitivity is widespread throughout biology. We review magnetic field effects on various physiological functions, organizing them based on the type of the applied magnetic fields, namely static, hypomagnetic, and oscillating magnetic fields, as well as isotope effects. We then review the radical pair mechanism as a potential unifying model for the described magnetic field effects, and we discuss plausible candidate molecules that might constitute the radical pairs. We review recent studies proposing that the quantum nature of the radical pairs provides promising explanations for xenon anesthesia, lithium effects on hyperactivity, magnetic field and lithium effects on the circadian clock, and hypomagnetic field effects on neurogenesis and microtubule assembly. We conclude by discussing future lines of investigation in this exciting new area of quantum biology related to weak magnetic field effects.

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“…In our previous works [1][2][3][4][5]18], these algorithms were partially presented and are not described in detail in this study but are our research's focus.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

“…Such studies are compounded by the lack of descriptions of relevant mathematical models of ischemic stroke in scientific literature, as well as drug-specific models of the pharmacokinetics of targeted delivery of PMC16 nanoparticles. All this is required for the development of In Silico instruments for preclinical and clinical studies of the neuroprotective potential of [ 25 Mg 2+ ] 4 PMC16 in the treatment of ischemic stroke [1][2][3][4] (Figure 1).…”

Section: Introduction Formulation Of the Problemmentioning

confidence: 99%

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives

Fursov¹,

Fursov²,

Bukhvostov³

et al. 2021

Pharmacogenetics

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Sharp blood circulation disorders are known for their capability to promote such abundant and hardly treatable pathologies as myocardium infarction and the ischemic brain stroke (“insult”). Noteworthy, the stroke — related brain tissue metabolic damages involve an essential ATP deplete clash along with a suppression of brain specific nucleotide — associated kinases and ATP synthase, both Mg2+ — dependent complex enzyme “machineries”. This itself makes the latter’s a legitimate target for some advanced pharmaceuticals as long as the drug — induced overstimulation of corresponding enzymatic activity is the case. Thus, magnetic isotope effects (MIE) of the nuclear spin possessing paramagnetic 25Mg2+ ions might modulate the brain creatine kinase, alfa-glycerophosphate kinase and pyruvate kinase catalytic activities in a way of a remarkable ATP hyperproduction required to compensate the hypoxia caused acute metabolic breakdown. To realize the Magnesium-25 pharmacological potential, a low-toxic amphiphilic cationite nanoparticles were introduced lately. Particularly, the Magnesium — releasing porphyrin-fullerene nanoadduct (cyclohexyl-C60-porphyrin, PMC16) has been proposed to meet expectations dealing with a targeted delivery of 25Mg2+ towards the brain ischemia surrounding areas. In order to optimize a multi-step [25Mg2+]4PMC16 preclinical trial scenario, the In Silico algorithms are to be developed and analyzed. In this study, these algorithms are in a focus with a special emphasize on a novel combination of slightly modified Gompertzian equation systems and a non-Markov population dynamics concept. This In Silico approach takes into account some literature-available patterns of brain hypoxia pathogenesis, the resulted simulation model could be considered as a promising tool for further research on experimental nanopharmacology of the ischemic stroke.

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A specific role of magnetic isotopes in biological and ecological systems. Physics and biophysics beyond

Cited by 27 publications

References 103 publications

Magnetic field effects in biology from the perspective of the radical pair mechanism

Magnetic field effects in biology from the perspective of the radical pair mechanism

Magnetic field effects in biology from the perspective of the radical pair mechanism

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives

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A specific role of magnetic isotopes in biological and ecological systems. Physics and biophysics beyond

Cited by 27 publications

References 103 publications

Magnetic field effects in biology from the perspective of the radical pair mechanism

Magnetic field effects in biology from the perspective of the radical pair mechanism

Magnetic field effects in biology from the perspective of the radical pair mechanism

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of 25Mg2+: Releasing Nanocationites - Background and Perspectives

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In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives