A specific serum IgA antibody discriminates pneumonia from colonization state in patients with Pseudomonas aeruginosa in sputum culture

Yamashita, Masanori; Hida, Yukio; Sugimoto, H; Takahashi, Naoki; Kimura, Hideki; Nakatomi, Yasuo; Yoshida, Haruyoshi; Ishizaki, Takeshi

doi:10.1016/j.mimet.2010.06.002

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2014

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“…Furthermore, in addition to a correlation with IgG, anti-pseudomonal IgA also correlated with the pro-inflammatory biomarkers CRP, IL-8 and cathepsins S and B. Although important in host defence against respiratory viruses, IgA may be less important in bacterial infections; however, measuring specific IgA titres from P. aeruginosa may be useful for differentiating between active infection and colonisation [28,34]. Some transmissible strains of P. aeruginosa are more virulent that non-transmissible strains, especially within the CF population.…”

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confidence: 99%