A spectrophotometric method for determining the amount of folic acid in fortified salt

Modupe, Oluwasegun; Maurras, Julie Bloquet; Diósady, Levente L.

doi:10.1016/j.jafr.2020.100060

Cited by 19 publications

(14 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The proposed approach was compared to several published FA preconcentration-determination approaches [5,7,[23][24][25][26], and Table 5 summarizes the main features for the proposed and the literature methods. According to the comparison in Table 5, it was clear the possibility…”

Section: Comparison Mnps-spe With Other Literature Methodsmentioning

confidence: 99%

“…It plays an important role in the development of red blood cells, fetal tissue and brain development, the production of RNA and DNA, and the growth of an infant [2]. A literature survey shows that there are several methods available for the assay of folic acid in different matrices, including spectrophotometry [3][4][5], liquid chromatography-tandem mass spectrometry (LC-MS/MS) [6], ultrahigh performance liquid chromatography [7], voltammetry [8], potentiometry [9], and spectrofluorometry [10]. In addition, different extraction methods of FA from different samples were reported, such as dispersive liquid-liquid microextraction [11], dispersive solid-phase extraction [12], and solid-phase extraction (SPE) [13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solid-phase extraction of folic acid from pharmaceutical formulations using modified magnetic iron oxide nanoparticles

Hadi¹,

Amer²

2022

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

ABSTRACT. A new analytical approach was suggested for the extraction and determination of folic acid in pharmaceutical samples using solid-phase microextraction. Magnetic iron oxide nanoparticles modified with sodium dodecylbenzene sulfonate (Fe3O4@SDBS) were used for the adsorption of folic acid (FA) from an aqueous solution and determined spectrophotometrically at λmax of 365 nm. The chemical and physical conditions that may affect the efficiency of extraction were studied and optimized, such as the pH of the solution, surfactant and adsorbent amount, extraction time, and desorption factors. A good linearity range of 0.2-6 μg/mL with correlation coefficient higher than 0.999 and limit of detection of 0.08 μg/mL were obtained, in addition to high extraction efficiency of 98% and enrichment factor 15. The method exhibited good accuracy and precision with recoveries ranged 98-102% and intraday precisions of best than 3.5% at all concentrations. The method was successfully applied for the determination of folic acid in pharmaceutical samples within a limited separation time. KEY WORDS: Folic acid, MNPs, Extraction, SDBS, Spectrophotometry, Solid phase extraction Bull. Chem. Soc. Ethiop. 2022, 36(2), 291-302. DOI: https://dx.doi.org/10.4314/bcse.v36i2.4

show abstract

Section: Comparison Mnps-spe With Other Literature Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solid-phase extraction of folic acid from pharmaceutical formulations using modified magnetic iron oxide nanoparticles

Hadi¹,

Amer²

2022

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

show abstract

“…The method described by Modupe et al (2020) was used to quantify folic acid in the salt and spray solution. For the spray solution, samples were diluted with 0.1 M Na 2 CO 3 at a ratio of 1:1000 , and the absorbance of the resulting solution was read at 285 nm.…”

Section: Materials and Experimental Methodsmentioning

confidence: 99%

Quadruple fortification of salt for the delivery of iron, iodine, folic acid, and vitamin B12 to vulnerable populations

Modupe

Diósady

2021

Journal of Food Engineering

Self Cite

View full text Add to dashboard Cite

A process for simultaneous delivery of iron, iodine, folic acid, and vitamin B 12 through salt as a potential and holistic approach to ameliorate anaemia and reduce maternal and infant mortality is presented. Two approaches for adding folic acid and B 12 to salt during double fortification with iron and iodine were investigated. Attempts to add both micronutrients through the iodine spray solution were unsuccessful. Hence, folic acid was added through a stabilized iodine solution, and B 12 was added through the iron premix. Four approaches used to incorporate B 12 into the iron premix were investigated: (1) co-extruding B 12 with iron, (2) spraying B 12 on the surface of the iron extrudate, (3) adding B 12 to the colour masking agent, and (4) adding B 12 to the outer coating. Of these approaches, coextrusion (1) was the best, based on the ease of production and stability of fortificants. The salt formulated with the solid iron-B 12 premix and sprayed iodine and folic acid solution contained 1000 ppm iron, 50 ppm iodine, 25 ppm folic acid, and 0.25 ppm B 12 . Over 98% of B 12 , 93% folic acid, and 94% iodine were retained after 6-month storage in the best formulation. This technology can simultaneously deliver iron, iodine, folic acid, and vitamin B 12 in a safe and stable salt enabling public health measures for improved health at a minimal additional cost.

show abstract

“…The amount of iodine and folic acid in the salt was reported as the percentage of the micronutrients in the freshly prepared samples. Iodine and folic acid in the salt were quantified as described by Modupe et al (2019) and Modupe et al (2020), respectively.…”

Section: Stability Study Of Fortified Saltmentioning

confidence: 99%

Folic Acid Fortification of Double Fortified Salt

Modupe

Siddiqui

Jonnalagadda

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

The addition of folic acid to Double Fortified Salt aims to ameliorate iron, iodine, and folic acid deficiencies in vulnerable populations. Folic acid was added either to the iodine spray solution or to the iron premix used to prepare salt fortified with iron and iodine. When added through the solution, sodium carbonate was needed to dissolve folic acid and to adjust pH. Alternately, folic acid was added either to the iron core or sandwiched between the core and the TiO2 layer of the ferrous fumarate premix. Folic acid and iodine were stable in all three cases, retaining more than 70% of the added micronutrients after six months at 45 oC/ 60-70% RH. Adding folic acid to the premix's iron core is preferred as folic acid retention was slightly higher, and the added folic acid did not impact a yellow colour to the salt. Folic acid in this salt was stable in cooking and did not affect selected cooked foods' sensory properties. The technology is a cost-effective approach for simultaneously combating iron, iodine, and folic acid deficiencies.

show abstract

A spectrophotometric method for determining the amount of folic acid in fortified salt

Cited by 19 publications

References 14 publications

Solid-phase extraction of folic acid from pharmaceutical formulations using modified magnetic iron oxide nanoparticles

Solid-phase extraction of folic acid from pharmaceutical formulations using modified magnetic iron oxide nanoparticles

Quadruple fortification of salt for the delivery of iron, iodine, folic acid, and vitamin B12 to vulnerable populations

Folic Acid Fortification of Double Fortified Salt

Contact Info

Product

Resources

About