A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16

Odrich, Marl G.; Lancaster, Wayne D.; Kenyon, Kenneth R.; Kelly, Lisa D.; Kornmehl, Ernest W.; Steinert, Roger F.; Grove, Arthur S.; Shore, John W.; Grégoire, Lucie; Albert, Daniel M.

doi:10.1016/s0161-6420(91)32218-8

Cited by 66 publications

(22 citation statements)

References 21 publications

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“…Furthermore, HPV subtyping analysis showed that high risk HPV DNA was not present in any of these patients. It is probably associated with geographic regions, lifestyle, or HPV detection multiply methods [11][12][13][14][15][16][17][18]. The above findings strongly support that the SCC of conjunctiva is not associated with HPV infection.…”

Section: Discussionmentioning

confidence: 63%

Expression of cell cycle-regulatory proteins, MIB-1, p16, p53, and p63, in squamous cell carcinoma of conjunctiva: not associated with human papillomavirus infection

Jung¹,

Lin²,

Chu³

et al. 2005

Virchows Arch

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Squamous cell carcinoma (SCC), the most common primary malignant tumor of the conjunctiva, has a variable clinical presentation and immunohistochemical profile. Abundant cell cycles exist, including MIB-1 (Ki67 antigen), p16, p53, and p63, within the conjunctiva SCC. This investigation first reports the expressions of cell cycle markers in SCC. A retrospective study was conducted between December 1976 and June 2004, comprising 13 consecutive patients with conjunctiva SCC who were treated with surgical excision. Detailed clinical parameters were also reviewed. Overexpression of MIB-1, p16, p53, and p63 genes were studied by immunohistochemistry. Genechip containing 39 subtypes was used to elucidate human papillomavirus (HPV). The study group contained 13 (100%) men, with a mean age of 68+/-18 years and follow-up period of 20+/-17 months. The sample included four (33%) SCC located in the left eye and two (17%) recurrent SCC. Overexpression of the p53 and p63 was considerably higher than that of the p16 (P<0.01). HPV DNA was not detected in any of the 13 cases. This work first examined the immunohistochemical overexpression of cell cycle (MIB-1, p16, p53, and p63) in SCC. This investigation then showed that the expression of cell cycles in SCC was associated with key tumor clinicopathological features. This approach can help distinguish the potential roles of cell cycle in the development of SCC.

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Section: Discussionmentioning

confidence: 63%

Expression of cell cycle-regulatory proteins, MIB-1, p16, p53, and p63, in squamous cell carcinoma of conjunctiva: not associated with human papillomavirus infection

Jung¹,

Lin²,

Chu³

et al. 2005

Virchows Arch

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“…The other instance (case 15) involved the left eye of a patient with bilateral conjunctival intraepithelial neoplasia, similar to patients reported on by Odrich and coworkers. 13 The cytology in our case disclosed dysplastic cells, while the biopsy showed normal conjunctiva. A repeat biopsy nearer the area where the cytologic aspiration was obtained revealed severe dysplasia.…”

Section: Discussionmentioning

confidence: 45%

Aspiration Cytology of the Conjunctival Surface

Grossniklaus

Stulting²,

Gansler³

et al. 2003

Acta Cytologica

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“…Of key interest in different benign conditions over lid margin are granuloma associated with hordeolum, keratoacanthoma, inverted follicular, seborrheic keratosis, amelanotic nevus, molluscum contagiosum and of alarming nature are squamous cell carcinoma and sebaceous gland carcinoma. 7 Surgical options for lid marginal tumors include: Simple excision, excision with conjunctival/mucous membrane graft, cryotherapy, photodynamic therapy, laser, combination with drugs like interferon 2-alpha and cimetidine.…”

Section: Discussionmentioning

confidence: 99%

Squamous Papilloma over Lid Margin: An Uncommon Presentation

Goyal¹,

Gupta²,

Dokania³

et al. 2016

International Journal of Advanced and Integrated Medical Sciences

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Papilloma is a histopathological term describing tumors of a classical finger-like or cauliflower morphology. Though benign, they carry profound malignancy potential and can present at numerous anatomical locations, such as skin, cervix, esophagus, respiratory tract, breast duct, etc. Papillomas over conjunctiva are not frequently encountered and carry special significance.A 60-year-old diabetic female presented with a left upper lid marginal sessile mass of 9 months duration with mild epiphora and foreign body sensation. On examination, a solitary, fleshy, sessile, polypoidal mass measuring 1 × 1 cm was seen, with irregular cauliflower-like surface present over lateral aspect of left upper lid, firm in consistency with raised edges. Visual acuity in right eye was 6/186/9 and left eye 6/366/9, intraocular pressure (IOP) was 14.6 mm Hg in both eyes by Schiötz tonometry. Complete excision of the lesion employing microsurgical technique with close apposition of lid margin using 6-0 Vicryl sutures was done under local anesthesia (LA). Histopathological examination revealed stratified squamous epithelium forming papillae with variable goblet cells supported by prominent branching fibrovascular cores in the center. A satisfactory cosmetic result was achieved. Follow-up of 6 months did not reveal any recurrence. A satisfactory functional and cosmetic result achieved.Squamous papillomas over lid margin are uncommon presentations. Even though benign they carry morbidity potential in the form of chronic epiphora, corneal erosions, and lid deformities if inadequately managed.

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A Spectrum of Bilateral Squamous Conjunctival Tumors Associated with Human Papillomavirus Type 16

Cited by 66 publications

References 21 publications

Expression of cell cycle-regulatory proteins, MIB-1, p16, p53, and p63, in squamous cell carcinoma of conjunctiva: not associated with human papillomavirus infection

Expression of cell cycle-regulatory proteins, MIB-1, p16, p53, and p63, in squamous cell carcinoma of conjunctiva: not associated with human papillomavirus infection

Aspiration Cytology of the Conjunctival Surface

Squamous Papilloma over Lid Margin: An Uncommon Presentation

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