A Spectrum of Solutions: Unveiling Non-Pharmacological Approaches to Manage Autism Spectrum Disorder

Abstract

Autism spectrum disorder (ASD) is a developmental disorder that causes difficulty while socializing and communicating and the performance of stereotyped behavior. ASD is thought to have a variety of causes when accompanied by genetic disorders and environmental variables together, resulting in abnormalities in the brain. A steep rise in ASD has been seen regardless of the numerous behavioral and pharmaceutical therapeutic techniques. Therefore, using complementary and alternative therapies to treat autism could be very significant. Thus, this review is completely focused on non-pharmacological therapeutic interventions which include different diets, supplements, antioxidants, hormones, vitamins and minerals to manage ASD. Additionally, we also focus on complementary and alternative medicine (CAM) therapies, herbal remedies, camel milk and cannabiodiol. Additionally, we concentrate on how palatable phytonutrients provide a fresh glimmer of hope in this situation. Moreover, in addition to phytochemicals/nutraceuticals, it also focuses on various microbiomes, i.e., gut, oral, and vaginal. Therefore, the current comprehensive review opens a new avenue for managing autistic patients through non-pharmacological intervention.

Unraveling the Endocannabinoid System: Exploring Its Therapeutic Potential in Autism Spectrum Disorder

“…Although post-natal LPS injection is not widely accepted as a model of ASD, additional studies suggest that suppressing FAAH may be a treatment option for diseases characterized by reduced social behavior. In mice exposed postnatally to LPS, disruptions to the ECS have been described (Doenni et al, 2016 ; Mondal et al, 2023 ). Early-life inflammation caused by a single LPS administration on post-natal day (PND) 14 impaired both male and female adolescent social play and non-play behavior.…”

Emerging Treatments and Therapies for Autism Spectrum Disorder: A Narrative Review

“…For example, omega-3, zinc, and iron can cause GI problems. Additionally, high levels of iron can cause iron poisoning, and high vitamin A consumption can be hepatotoxic [ 60 ]. Although many patients with ASD have nutritional insufficiencies, it is important to counsel patients and families on the side effect profiles of supplements and make recommendations based on specific deficiencies.…”