A spontaneously vanishing primary cerebral lymphoma "ghost tumour"

Takekawa, Hidehiro; Hozumi, Akira; Hirata, Ken; Yamazaki, Kiyohiro

doi:10.1136/jnnp.2007.132282

Cited by 11 publications

(5 citation statements)

References 3 publications

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“…7 This theory is largely founded on their remarkable effect in the treatment of lymphoreticular malignancies such as leukemia and in primary CNS lymphomas. 17,18 A striking feature of intracranial germinomas is the considerable presence of tumor-infiltrating lymphocytes (TIL). The number of TILs could be so numerous as to obscure the underlying tumor cells and, as exhibited by our case's first biopsy specimen, can pose diagnostic challenges.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report

Woo

Kakaizada

Chan

et al. 2018

British Journal of Neurosurgery

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Section: Discussionmentioning

confidence: 99%

Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report

Woo

Kakaizada

Chan

et al. 2018

British Journal of Neurosurgery

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“…In all cases described so far, the patient was immunocompetent. 11,12 In the present case, we show that spontaneous regression of a cerebral lymphoma without any treatment (including corticosteroids) is also possible in an immunodeficient patient. We observed this in a liver transplant recipient who was under long-term immunosuppressive treatment with tacrolimus.…”

Section: Discussionmentioning

confidence: 85%

Spontaneous Regression of an Intracerebral Lymphoma (Ghost Tumor) in a Liver-Engrafted Patient

Körner

Raab²,

Brandis³

et al. 2011

The Neurologist

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Posttransplantation lymphoproliferative disorder involving the central nervous system is a rare and serious complication associated with solid organ transplantation. We report a liver transplant recipient who noticed unbalance, dizziness, and headache 30 months after transplantation. Magnetic resonance imaging (MRI) showed a space-occupying lesion in the corpus callosum and adjacent parenchyma of the left hemisphere. In the following month, the neurological symptoms and the MRI findings regressed without any treatment. Four months later the patient developed a left-sided hemiparesis. MRI now revealed a considerable increase of the known lesion and new lesions in other locations. Stereotactic biopsy showed a B-cell non-Hodgkin lymphoma of high malignancy. A spontaneous regression of cerebral lymphoma is possible, even in immunosuppressed patients. Hence, this diagnosis must not be dismissed if there is spontaneous regression of a lesion in the MRI or an amelioration of the clinical symptoms. Owing to the high mortality rate associated with this disease, prompt pathologic diagnosis is required to initiate appropriate therapy.

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“…Spontaneous regression of malignant tumors is an unusual phenomenon which have been observed in malignant melanomas, renal cell carcinomas, neuroblastomas, testes germ cell tumors, and brain tumors [4,5]. Spontaneously disappearing or decreasing of the initial brain mass volume to ≤ 70% before establishing the definitive diagnosis, observed by MRI or computed tomography (CT), is defined as vanishing tumor, tumor regression, ghost tumor, or burned-out tumor [4][5][6][7][8][9]. Primary CNS lymphoma (PCNSL) is the commonest pathology in vanishing brain tumors [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of congenital brain tumors: a report of two cases

2021

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Background Vanishing brain tumor is defined as spontaneously disappearing or decreasing of the initial brain mass volume to ≤ 70% before establishing the definitive diagnosis. The condition is rare and can be attributed to different factors. The exact mechanism is under debate, but the increasing rate and accuracy of neuroimaging studies and occurrence of similar scenario in other pathologies rather than brain tumors can be of particular importance in finding vanishing brain lesions. Case report We present two unusual cases of congenital brain masses which underwent spontaneous shrinkage within the first months of life. Conclusion The condition is scarcely observed in congenital brain masses. As congenital brain lesions are distinct entities with peculiar characteristics, this rare phenomenon may reflect different aspects in this age group.

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A spontaneously vanishing primary cerebral lymphoma "ghost tumour"

Cited by 11 publications

References 3 publications

Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report

Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report

Spontaneous Regression of an Intracerebral Lymphoma (Ghost Tumor) in a Liver-Engrafted Patient

Spontaneous regression of congenital brain tumors: a report of two cases

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