A Sporadic Desmoid Tumor: an Exceptional Pancreatic Cystic-Solid Mass

Ardakani, Jalal Vahedian; Mehrjardi, Ali Zare; Wadji, Massoud Baghai; Saraee, Amir

doi:10.1007/s12262-015-1403-8

Cited by 7 publications

(4 citation statements)

References 8 publications

(9 reference statements)

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“…The diagnosis was confirmed by pathology and the patient underwent surgery without further complications. Słowik-Moczydłowska et al [1] described a 13-year-old Caucasian boy with recurrent pain for 2 months in the left hypochondrium of his abdomen. The cystic lesion in the hilum of the spleen and tail of the pancreas was discovered in ultrasonography and an abdominal-enhanced CT scan.…”

Section: Discussionmentioning

confidence: 99%

“…A retroperitoneal neoplasm such as a pancreatic desmoid tumor is more common in patients with familial polyposis coli and Gardner syndrome and can occur after abdominal surgery. It may present with vague abdominal pain, cramping, and nausea [1] . Such tumors are usually detected on an abdominal computed tomography [CT] scan or magnetic resonance imaging and confirmed with a pathology exam.…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic cystic desmoid tumor following metastatic colon cancer surgery: A case report

Shayesteh

Salimian

Fouladi

et al. 2020

Radiology Case Reports

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Desmoid tumors are rare, benign, and locally aggressive neoplasms that stem from connective tissue that have high rates of recurrence after surgery. Intra-abdominal desmoid-type fibromatosis can arise in 2 forms: sporadic or hereditary (associated with familial adenomatous polyposis and Gardner syndrome). The diagnosis of desmoid-type tumors is based on imaging modalities and histopathological examination. The primary treatment is resection surgery. We report a 64-year-old male with a distal pancreatic desmoid tumor. We focus on tumor management by the application of radiological modalities and pathological analysis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pancreatic cystic desmoid tumor following metastatic colon cancer surgery: A case report

Shayesteh

Salimian

Fouladi

et al. 2020

Radiology Case Reports

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“…The differential diagnosis of desmoid tumor includes neuroendocrine tumor, lymphoma, retractile sclerosing mesenteritis, gastrointestinal stromal tumor, and mesenteric metastases (11). Since desmoids scarcely cause necrosis (12) and bleeding (13), cystic formation of desmoids has rarely been reported; indeed, only 13 cases have been published in the English literature, as shown in Table (origin: 12 pancreas and 1 mesenterium) (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Due to its rarity, preoperative diagnoses of solid-cystic desmoids are very difficult, and these lesions are often misdiagnosed as malignant tumors, such as a pancreatic cancer (14-16), a neuroendocrine tumor with cystic changes 17, a cystic neoplasm of the pancreas (18)(19)(20)(21)(22), and an inflamed teratoma (23).…”

Section: ×200) C) the Cystic Wall Was Covered By Flattened Columnar mentioning

confidence: 99%

An Intra-abdominal Solid-cystic Desmoid That Emerged after Distal Gastrectomy

et al. 2019

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Desmoid is a locally aggressive fibroblastic neoplasm, typically showing a heterogeneous solid mass, and its pathogenesis is multifactorial, including surgical scars. We herein report a rare case of an intra-abdominal desmoid, consisting of solid and cystic components covered with epithelial linings, that emerged after distal gastrectomy. The preoperative diagnosis was inconclusive, so laparotomy was performed. Histopathology of the solid component showed proliferating spindle cells, which were positive for beta-catenin in their nuclei. Clinicians need to bear in mind that desmoids can appear in a solid-cystic form, and immunostaining of betacatenin should be applied for tumors that emerge around postoperative wounds.

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“…Desmoid fibromatosis involving the pancreas is very rare, with to our knowledge only 31 cases previously reported in the English‐language literature 12‐26 . Due to their rarity and non‐specific imaging findings, pancreatic desmoid tumors are often initially suspected to be malignant tumors, and only identified as fibromatosis after resection.…”

Section: Introductionmentioning

confidence: 99%

A rare sporadic pancreatic desmoid fibromatosis diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration: Case report and literature review

Stone

Mallery

Stewart

et al. 2020

Diagnostic Cytopathology

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Intra‐abdominal desmoid fibromatosis (also known as desmoid tumor) is a rare benign but often locally aggressive infiltrative fibrous proliferation. Pancreatic desmoid fibromatosis is even rarer, with only 31 cases previously reported in the English‐language literature. These tumors present a distinct diagnostic challenge due to their rarity and non‐specific image findings and presentation, with most cases diagnosed as desmoid fibromatosis only after surgical resection. This report presents a rare case of pancreatic desmoid fibromatosis in a 72 year old man, who on a follow‐up CT for a previously diagnosed angiomyolipoma of the kidney was found to have a 4.0 cm pancreatic tail mass. This was sampled pre‐operatively by endoscopic ultrasound (EUS)‐guided fine‐needle aspiration (FNA). Examination of the cytology material showed a low‐grade spindle cell lesion. Immunohistochemistry (IHC) performed on FNA cell block showed the lesional cells to be positive for beta‐catenin, consistent with fibromatosis. Additional mutational analysis on cell block material revealed the characteristic CTNNB1 gene mutation (T41A), confirming the diagnosis. The mass was then surgically resected and again confirmed to be desmoid fibromatosis on histopathologic examination. On review of previously published cases of pancreatic desmoid fibromatosis, most were initially suspected to be some type of pancreatic neoplasm and were not biopsied prior to surgical resection. This case suggests a potential key role for fine‐needle aspiration cytology in the preoperative diagnosis of pancreatic and other intra‐abdominal desmoid tumors, particularly as evidence emerges that non‐surgical treatment may be a viable first option for some cases.

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A Sporadic Desmoid Tumor: an Exceptional Pancreatic Cystic-Solid Mass

Cited by 7 publications

References 8 publications

Pancreatic cystic desmoid tumor following metastatic colon cancer surgery: A case report

Pancreatic cystic desmoid tumor following metastatic colon cancer surgery: A case report

An Intra-abdominal Solid-cystic Desmoid That Emerged after Distal Gastrectomy

A rare sporadic pancreatic desmoid fibromatosis diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration: Case report and literature review

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