A spotted fever in Tobia, Colombia. 1937.

Patiño, Luz Helena; Afanador, A.; Paul, Joan

doi:10.7705/biomedica.v26i2.1408

Cited by 11 publications

(4 citation statements)

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“…These conditions affected almost all inhabitants and seemed to lead to severe impairment in the quality of life of most, as well as to some individuals' reduced general activity. Such a high prevalence of tick bites associated with incapacitating chronic pruritus is noteworthy and deserves attention, also because ticks are known vectors for rickettsiae in South America, 6‐12 and outbreaks of the spotted fever group rickettsioses have occurred in another area of Colombia.…”

Section: Introductionmentioning

confidence: 99%

Tickbite‐associated chronic pruritic lesions in an Afro‐descendant population in the Cauca Department, Colombia. I. Clinical features and impact on health

et al. 2020

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Background During a health survey in a remote area in southwest Colombia, it became apparent that a high percentage of the population suffered from chronic pruritus in association with high numbers of ticks and tickbites. Objective To determine the clinical features and severity of tickbite-associated pruritus. Method At twotime points-8 weeks apart to account for seasonal effectsa crosssectional study was conducted encompassing physical examination of the population, histological analysis of skin biopsies, and determining serum for antibodies against spotted fever (SFG) rickettsiae and typhus group (TG) rickettsiae. Ticks were identified using morphological criteria, and infection by rickettsiae was determined by PCR. Results About 94.5% of the population (95% CI 92-97%) showed clinical signs of a pruritic arthropod reaction and of chronic pruritus with lichenoid papules and hyper-and hypopigmented nodules on otherwise noninflamed skin. Pruritus markedly impaired the quality of life in terms of sleeping disturbances. No signs for other diseases were observed. Chronic pruritus appeared to be because of repeated tickbites and scratching, but not because of other dermatological or medical conditions. Antibodies against SFG and TG-rickettsiae were detected at 79.0% (95% CI 73-86) and 3.6% (95% CI 0.7-6), respectively. Ticks were identified as Amblyomma cajennense. Conclusion Remarkably high exposure to tick bites caused an unusually high rate of acute and chronic pruritus and markedly impaired quality of life of the investigated rural community. This underlines the necessity of public health measures and surveillance of rickettsial disease. Colombian village in southwest Colombia, where people reported about repeated infestations with ticks in the field, associated with an unusually persistent or chronic pruritic dermatosis. These conditions affected almost all inhabitants and

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Section: Introductionmentioning

confidence: 99%

Tickbite‐associated chronic pruritic lesions in an Afro‐descendant population in the Cauca Department, Colombia. I. Clinical features and impact on health

et al. 2020

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“…An outbreak of RMSF occuring in Tobia, Colombia was reported in 1937 and was remarkable for a 95% case fatality rate [ 55 ]. The disease was forgotten until two cases were identified in 2003 in Villeta, Colombia—a community near Tobia [ 56 ].…”

Section: Clinical and Epidemiological Significance Of Rocky Mountain ...mentioning

confidence: 99%

A Vaccine for Canine Rocky Mountain Spotted Fever: An Unmet One Health Need

et al. 2022

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Outbreaks of life-threatening Rocky Mountain spotted fever in humans and dogs associated with a canine-tick maintenance cycle constitute an important One Health opportunity. The reality of the problem has been observed strikingly in Mexico, Brazil, Colombia, and Native American tribal lands in Arizona. The brown dog tick, Rhipicephalus sanguineus sensu lato, acquires the rickettsia from bacteremic dogs and can maintain the bacterium transtadially to the next tick stage. The subsequent adult tick can then transmit infection to a new host, as shown by guinea pig models. These brown dog ticks maintain spotted fever group rickettsiae transovarially through many generations, thus serving as both vector and reservoir. Vaccine containing whole-killed R. rickettsii does not stimulate sufficient immunity. Studies of Rickettsia subunit antigens have demonstrated that conformationally preserved outer-membrane autotransporter proteins A and B are the leading vaccine candidates. The possibility of a potentially safe and effective live attenuated vaccine has only begun to be explored as gene knockout methods are applied to these obligately intracellular pathogens.

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“…In Colombia, the presence of clinical rickettsiosis in humans caused by SFG rickettsiae like Rickettsia rickettsii and Rickettsia parkeri strain Atlantic rainforest has been demonstrated (Acosta et al, 2006;Arboleda et al, 2020;Ávila-Aguirre et al, 2020;Cuéllar-Sáenz et al, 2023;Faccini-Martínez et al, 2016a;Gómez-Quintero et al, 2017;Hidalgo, 2010;M. Hidalgo et al, 2007;Luis Patiño Camargo, 2006;Pacheco, 2008;Patiño et al, 2006;Quintero Vélez et al, 2012). In addition, tick-associated rickettsial pathogens have been detected in ticks from Colombia (Arroyave et al, 2020;Cardona et al, 2020;A.P.…”

Section: Introductionmentioning

confidence: 99%

Detection of Rickettsia spp. in questing ticks (Acari: Ixodidae) from forest fragments adjacent to agricultural and livestock farms in Casanare, Colombia

Rodríguez-Bautista,

Fuya-Oviedo,

Nijhof

et al. 2024

Preprint

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This study aimed to describe the diversity of ixodid tick species in rural forest areas of Yopal and Aguazul, Department of Casanare, Colombia, and to evaluate the presence of tick-borne Rickettsia sp., potentially impacting animal and human health. A cross-sectional study was conducted on questing ticks collected from forested farm areas that keep livestock and/or conduct agricultural activities. All ticks were subjected to DNA extraction and tested by PCR amplifying fragments of three rickettsial genes: gltA, htrA, and ompA. A total of 852 individual ticks (larvae, nymphs, and adults) and 15 additional larvae clusters were collected and identified as Amblyomma mixtum, Amblyomma cf. parvum, Amblyomma dissimile, Amblyomma spp., and Dermacentor spp. Rickettsia organisms were detected by PCR in 7.0% (16/230) of the individual larvae, 0.2% (1/488) of the nymphs, and 1.5% (2/134) of the adults. “Candidatus Rickettsia colombianensi” and Rickettsia amblyommatis were detected in 1.52% (13/852) and 0.47% (4/852) of the ticks, respectively. In addition, a novel genotype, Rickettsia sp. genotype Yopal, phylogenetically closest to Rickettsia canadensis, was identified in two A. mixtum males. Several tick and Rickettsia species were found in the study areas, suggesting the need for an in-depth study of rickettsiosis in the Department of Casanare and across Colombia. Priority areas for future studies include investigating the molecular, clinical, and epidemiological features of the presentation of tick species and the possible participation of “Ca. R. colombianensi”, R. amblyommatis, and “Rickettsia sp. Yopal genotype of A. mixtum” to understand their role in human rickettsiosis in the study region.

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A spotted fever in Tobia, Colombia. 1937.

Cited by 11 publications

References 0 publications

Tickbite‐associated chronic pruritic lesions in an Afro‐descendant population in the Cauca Department, Colombia. I. Clinical features and impact on health

Tickbite‐associated chronic pruritic lesions in an Afro‐descendant population in the Cauca Department, Colombia. I. Clinical features and impact on health

A Vaccine for Canine Rocky Mountain Spotted Fever: An Unmet One Health Need

Detection of Rickettsia spp. in questing ticks (Acari: Ixodidae) from forest fragments adjacent to agricultural and livestock farms in Casanare, Colombia

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