A Stability-Indicating LC Method for Rimonabant

Raju, T.; Ravikumar, Muttineni; Kumar, K. Vijay; Raghavachary, K. S. V.; Varma, M. Satish; Rao, Ch.Surya Naga Malleswara; Swamy, P. Yadagiri

doi:10.1365/s10337-008-0861-6

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…The Schiff bases constitute one of the most active class of the compound posses biological activities such as anti-tubercular 1 , anticancer 2 , plant growth inhibitors 3 , insectisidal [4][5] , CNS depressant, 6 , antibacterial [7][8][9][10][11][12][13][14] , The Schiff bases can be prepared by the acid catalysed reaction of amine and ketone or aldehyde. Schiff bases are used as starting material for the synthesis of various bioactive heterocyclic compound like 2-azetidinones, benzoxazines and formazans.…”

Section: Introductionmentioning

confidence: 99%

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2012

IJPSR

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Heterocyclic Compounds having a valuable place in a Heterocyclic Chemistry and Heterocyclic Compounds having an excellent properties such as drugs, dyes etc, These compounds shows anti-microbial, anti-fungal, anti-bacterial, anti-inflammatory, anti-diabetic, anti-hypertensive etc. properties. In present investigation, we have prepared 2-4-{[(substitutedphenyl)imino]methyl} phenoxy)acetohydrazide from amine of (4-{[substitutedphenyl)imino] methyl}phenoxy)acetic acid and Hydrazine hydrate in presence of ethanol. The intermediate (4-{[(substitutedphenyl)imino]methyl} phenoxy) acetic acid from (4-formylphenoxy)acetic acid and substitutedaniline by using ethanol as a solvent. Compound having an excellent properties regarding as per as anti cancer and HIV as compare to this compound. Physical properties of pure crystallized substance 2-4-{[(substitutedphenyl) imino]methyl}phenoxy) acetohydrazide like M.P., elementary analysis and spectral data of compound and such as IR and NMR will be evaluated and confirm the structure of compound.

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Section: Introductionmentioning

confidence: 99%

Untitled

2012

IJPSR

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“…Chemically, it is 5-(4-Chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide mono hydrochloride (Figure1), with empirical formula of C 22 H 21 C l3 N 4 O.HCl and the molecular weight of 500.29. Literature review reveals that few analytical methods were evoked for the estimation of RMTH in human plasma (Ramakrishna et al, 2007;Melissa et al, 2008;Fouad et al ., 2009), in human plasma and hair (Stanislas Grassin et al, 2008), in rat plasma (Rajesh et al, 2009), in monkey plasma (Javors et al, 2010), identification of endo cannabinoids and related compounds in fat cells by different analytical techniques (Marie Paule et al, 2007), HPLC method for bio analytical application with rimonabant (Uttam et al, 2009), simultaneous estimation of rimonabant with orlistat (Wei et al, 2010) and with four major species in slimy foods (Zhou et al, 2010) Detection and quantification of synthetic drugs in herbal slimming formula (Sofian et al, 2009) , pharmacokinetic studies of RMTH in rats (Zoe et al, 2006), stability indicating assay of RMTH in bulk and pharmaceutical dosage forms by HPLC (Felipe et al, 2010;Satyanarayana et al, 2009), by HPTLC (Rajesh et al, 2010), estimation of RMTH in bulk and pharmaceutical dosage forms using external standard method (Sreekanth et al, 2009) and spectrophotometric estimation of RMTH in marketed formulations (Manas et al, 2009) were reported. In the absence of official RMTH monograph in the pharmacopoeias, including the European Pharmacopoeia, British Pharmacopoeia and United States Pharmacopoeia, development of such a method may prove all the more useful.…”

Section: Introductionmentioning

confidence: 99%

A novel validated RP-HPLC method development for the estimation of rimonabant hydrochloride in bulk and tablet dosage forms

Nama¹

2011

Afr. J. Pharm. Pharmacol.

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A novel, simple and economic reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of rimonabant hydrochloride in bulk and tablet dosage forms with greater precision and accuracy. Separation was achieved on C18 column (250X4.6mm i.d., 5µm) in isocratic mode using methanol and water in the ratio 90:10 (v/v) as mobile phase, pumped in to the column at flow rate of 1 ml/min and the detection of eluent from the column was carried out using variable wavelength detector at 280 nm. The total run time was 10 min and the column was maintained at ambient temperature. The retention times of rimonabant hydrochloride and saquinavir mesylate were 5.760 min and 4.657 min, respectively. The standard curves were linear over the concentration range of 0.2-10 µg/ml and the LOD and LOQ values for rimonabant hydrochloride were 0.0113µg/ml and 0.0345µg/ml, respectively. The percentage recovery was found to be 100 to 100.22 and the % RSD of intraday and inter day precision was found to be 0.572 and 0.549, respectively. The percentage amount of two different marketed tablet formulation of rimonabant hydrochloride was found to be 100.4 and 100.5%. The method was validated as per ICH guidelines. Validation studies demonstrated that the proposed RP-HPLC method is simple, specific, rapid, reliable and reproducible. The high recovery and low relative standard deviation confirm the suitability of the proposed method for the routine quality control analysis of rimonabant hydrochloride in bulk and tablet dosage forms.

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Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection

Hadwiger

Trehy

et al. 2010

Journal of Chromatography A

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A Stability-Indicating LC Method for Rimonabant

Cited by 5 publications

References 6 publications

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A novel validated RP-HPLC method development for the estimation of rimonabant hydrochloride in bulk and tablet dosage forms

Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection

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