A stable home‐base promotes allocentric memory representations of episodic‐like everyday spatial memory

Broadbent, Nicola; Lumeij, Lucas Berend; Corcoles, Marta; Ayres, Alice I; Ibrahim, Mohammad Zaki Bin; Masatsugu, Brittany; Moreno, Andrea; Carames, Jose-Maria; Begg, Elizabeth; Strickland, Lauren; Mazidzoglou, Theofilos; Padanyi, Anna; López, Mayra; Takeuchi, Tomonori; Peters, Marco; Morris, Richard; Tse, Dorothy

doi:10.1111/ejn.14681

Cited by 10 publications

(13 citation statements)

References 48 publications

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“…In addition, we studied the within-and between-session strategies that mice employ in this task. Altering the start box location between and after encoding trials confirmed that mice primarily used an allocentric (world-centered) rather than egocentric (body-centered) reference frame (Figure S3A-D; 33 ). Within a session, mice focused their search progressively closer to the rewarded arm ( Figure S3E) and revisited non-rewarded arms less than expected from chance ( Figure S3F).…”

Section: Resultsmentioning

confidence: 83%

Spaced training enhances memory and prefrontal ensemble stability in mice

Glas

Hübener

Bonhoeffer

et al. 2020

Preprint

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SummaryMemory is substantially improved when learning is distributed over time, an effect called “spacing effect”. So far it has not been studied how spaced learning affects neuronal ensembles presumably underlying memory. In the present study, we investigate whether trial spacing increases the stability or size of neuronal ensembles. Mice were trained in the “everyday memory” task, an appetitive, naturalistic, delayed matching-to-place task. Spacing trials by 60 minutes produced more robust memories than training with shorter or longer intervals. c-Fos labeling and chemogenetic inactivation established the necessity of the dorsomedial prefrontal cortex (dmPFC) for successful memory storage. In vivo calcium imaging of excitatory dmPFC neurons revealed that longer trial spacing increased the similarity of the population activity pattern on subsequent encoding trials and upon retrieval. Conversely, trial spacing did not affect the size of the total neuronal ensemble or the size of subpopulations dedicated to specific task-related behaviors and events. Thus, spaced learning promotes reactivation of prefrontal neuronal ensembles processing episodic-like memories.

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Section: Resultsmentioning

confidence: 83%

Spaced training enhances memory and prefrontal ensemble stability in mice

Glas

Hübener

Bonhoeffer

et al. 2020

Preprint

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“…Altering the start box location between and after ETs confirmed that mice primarily used an allocentric (world-centered) rather than egocentric (body-centered) reference frame (Figures S2A-S2D). 33 Within a session, mice revisited non-rewarded arms less than expected from chance (Figure S2E) and focused their search progressively closer to the rewarded arm (Figure S2F). Between sessions, the previous session's retrieval performance did not affect the next session's retrieval performance (Figure S2G), suggesting that a successfully stored memory did not interfere with learning of a new memory.…”

Section: Resultsmentioning

confidence: 97%

“…5 However, delayed memory stabilization was not observed in two earlier studies using the everyday memory task. 7,40 This variation can possibly be attributed to methodological differences such as the animal model, 7,40 number of ETs, 40 navigational strategy, 33 handling, or intertrial sleep epochs.…”

Section: Spaced Training Strengthens Memorymentioning

confidence: 99%

Spaced training enhances memory and prefrontal ensemble stability in mice

et al. 2021

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“…Initially, we established that our one-session learning paradigm in a Plusmaze led to long-term memory (24 h test) and was dependent on sleep. Plusmaze learning was performed in the event arena ( 11 – 13 ), with curtains included to limit the influence of uncontrolled room cues, but with large cues for spatial orientation placed on the curtain. Further, the walls of the event arena were inverted so that a cross-shaped maze was created covering 1.5 × 1.5 m with a track width of 15 cm.…”

Section: Resultsmentioning

confidence: 99%

Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day

Aleman‐Zapata

Morris

Genzel

2022

Proc. Natl. Acad. Sci. U.S.A.

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Memory reactivation during non–rapid-eye-movement ripples is thought to communicate new information to a systems-wide network and thus can be a key player mediating the positive effect of sleep on memory consolidation. Causal experiments disrupting ripples have only been performed in multiday training paradigms, which decrease but do not eliminate memory performance, and no comparison with sleep deprivation has been made. To enable such investigations, we developed a one-session learning paradigm in a Plusmaze and show that disruption of either sleep with gentle handling or hippocampal ripples with electrical stimulation impaired long-term memory. Furthermore, we detected hippocampal ripples and parietal high-frequency oscillations after different behaviors, and a bimodal frequency distribution in the cortical events was observed. Faster cortical high-frequency oscillations increased after normal learning, a change not seen in the hippocampal ripple-disruption condition, consistent with these having a role in memory consolidation.

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A stable home‐base promotes allocentric memory representations of episodic‐like everyday spatial memory

Cited by 10 publications

References 48 publications

Spaced training enhances memory and prefrontal ensemble stability in mice

Spaced training enhances memory and prefrontal ensemble stability in mice

Spaced training enhances memory and prefrontal ensemble stability in mice

Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day

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