Sulfides and CO 2 are the main pollutants that cause environmental acidification and the greenhouse effect. However, the rational use of these pollutants can not only save resources but also improve the environment. The two-interpenetrated MOF-150 was prepared by the photoresponsive 4,4′,4″-nitrilotribenzoic acid (H 3 NTB) ligand and Zn 4 O clusters, and it exhibits excellent optical activity derived from H 3 NTB. Especially as the substrate, thioanisole is oxidized to sulfoxide with medicinal value after 10 h of Xe light irradiation, and the conversion rate of 98% and the selectivity of 100% are obtained. Higher photocatalytic performance is also observed when the substrate is extended to other sulfides (7 examples). At the same time, MOF-150 has an excellent performance in the capture and recycling catalytic fixation of CO 2 . With epichlorohydrin as the reaction substrate, the cycloaddition efficiency of CO 2 can reach over 99%. When it is extended to other epoxides, satisfactory cycloaddition efficiency was also obtained (7 examples). Therefore, MOF-150 is a promising heterogeneous catalyst with high catalytic efficiency and selectivity for a wide range of substrates.