A standard nomenclature for structures of the kidney

Kriz, Wilhelm; Bankir, Lise; Bulger, Ruth Ellen; Burg, Maurice B.; Goncharevskaya, O. A.; Imai, Masashi; Kaissling, Brigitte; Maunsbach, Arvid B.; Moffat, D. B.; Morel, Francois; Morgan, Trefor; Natochin, Yu. V.; Tisher, C. Craig; Venkatachalam, Manjeri A.; Whittembury, Guillermo; Wright, Fay

doi:10.1007/bf00581654

Cited by 49 publications

(25 citation statements)

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“…Unfortunately, in almost all studies, ODC and OAT activities have been measured in supernatants of crude homogenates of the whole female mouse kidney. This approach does not take into account the high degree of cellular heterogeneity of the kidney [2,13,25]. The glomeruli and each portion of the nephron including the whole collecting duct are composed of distinct types of cells [10].…”

Section: Olivier Levillain · Jean-jacques Diaz Isabelle Reymond · Denmentioning

confidence: 99%

Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase

Levillain

Diaz

Reymond

et al. 2000

Pflugers Arch - Eur J Physiol

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The fate of ornithine in the nephron of the female OF-1 Swiss mouse remains unknown. The aim of the present study was to identify the nephron segments containing the key enzymes involved in ornithine metabolism: ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT). Viable tubules isolated by microdissection were incubated with [1-14C]ornithine to study the oxidative pathway. Other tubules were permeabilized to measure the ODC activity. Ornithine was decarboxylated in all intact tubules. Gabaculine, a suicide inhibitor of OAT, and rotenone sharply decreased the production of 14CO2 from [1-14C]ornithine. No ODC activity was found in permeabilized tubules isolated from untreated mice. Testosterone increased ODC activity in the proximal tubule substantially and to a minor extent in other nephron segments. In situ hybridization showed ODC messenger ribonucleic acid (mRNA) to be absent in kidneys of untreated females but abundant in the cortex and the outer stripe of the outer medulla of testosterone-treated female mice. The whole proximal tubule contained a great density of silver grains corresponding to ODC mRNA. In conclusion, no basal ODC activity was found in the nephron of female mice. The testosterone-inducible ODC is localized mainly in the proximal tubule, but is also present in distal tubules and collecting ducts. OAT is distributed along the whole nephron, but its activity is higher in proximal tubules than in distal tubules.

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Section: Olivier Levillain · Jean-jacques Diaz Isabelle Reymond · Denmentioning

confidence: 99%

Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase

Levillain

Diaz

Reymond

et al. 2000

Pflugers Arch - Eur J Physiol

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“…Slides immunostained with various antibodies were counterstained with Harris Haematoxylin as previously described (Oberley et al, 1990 to stain nuclei. The nomenclature used for designating nephron segments and types of cell is that of Kriz & Bankir (1988).…”

Section: Immunoperoxidase Studiesmentioning

confidence: 99%

Immunohistochemical localization of antioxidant enzymes during hamster kidney development

1995

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Immunolocalization studies of hamster kidney development were performed using polyclonal antibodies to antioxidant enzymes, including antibodies to copper, zinc and manganese superoxide dismutases, catalase, glutathione peroxidase and glutathione S-transferases and their subunits. Antibodies to extracellular matrix proteins were also studied to determine the temporal sequence between expression of immunoreactive protein for basement membrane proteins, which serve as markers of embryonic induction of nephron development, and antioxidant enzyme expression in kidney development. Immunoreactive proteins for antioxidant enzymes were not detectable in the developing kidney until after extracellular matrix proteins had been deposited. However, immunoreactive proteins for the antioxidant enzymes copper, zinc and manganese superoxide dismutases, catalase, and alpha class glutathione S-transferase Ya subunit were detected in renal tubules before birth. mu class glutathione S-transferase subunits Yb1 and Yb2 stained transitional epithelium at high levels before birth. Our results indicate: (1) each type of kidney cell has a unique antioxidant enzyme profile, (2) antioxidant enzymes are expressed in different types of cell at different times during development, but antioxidant enzyme immunoreactive protein was not present until after immunoreactive proteins for extracellular matrix molecules were detected, and (3) certain antioxidant enzymes are present before birth, indicating that high oxygen tension present at birth is not crucial for induction of immunoreactive protein.

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“…They can be observed entering the kidney with the renal artery and vein following the intrarenal vasculature and reaching the interlobular arteries (cortical radial arteries, Kriz and Bankir 1988) as far as the nephrogenic zone which they do not penetrate. In the juxtamedullary midportion of the kidney, CGRP-IN may be observed associated with glomeruli and glomerular arterioles, and are also seen in the renal capsule.…”

Section: Afferent Innervationmentioning

confidence: 99%

The rat renal nerves during development

Liu

Barajas

1993

Anat Embryol

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The prenatal and postnatal development of the innervation of the rat kidney has been investigated using immunocytochemical methods. The efferent innervation was studied using dopamine-beta-hydroxylase and neuropeptide Y antibodies. Calcitonin gene related peptide and substance P antibodies were used to investigate the afferent innervation. Kidneys from embryos of 14 to 20 days, from newborn rats, and from animals of 4, 10, 12, 21, 38, 60, and 90 days of age were studied. Slices of whole kidneys were analyzed, and frozen sections were used to investigate the location of the nerves in more detail. Both afferent and efferent nerves are observed inside the kidney by embryonic day 16. At birth, the afferent nerves are found (1) forming a rich plexus in the renal pelvis; (2) associated with the renal vasculature as far as the interlobular arteries (cortical radial arteries) and (3) in the corticomedullary connective tissue. The efferent innervation appears, at birth, to extend to the interlobular arteries and to the afferent arterioles of the perihilar juxtamedullary nephrons. The efferent innervation increases rapidly during the following days, and by postnatal day 21 a distribution of the innervation similar to that of the adult is observed. While the afferent innervation reaches the major target regions of the kidney by birth, the efferent does most of its expansion into the kidney postnatally. Afferent and efferent fibers are found, extrarenally and intrarenally, in the same nerve bundles. This proximity between afferent and efferent fibers may represent anatomical bases for their interaction in the adult as well as during development.

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A standard nomenclature for structures of the kidney

Cited by 49 publications

References 0 publications

Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase

Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase

Immunohistochemical localization of antioxidant enzymes during hamster kidney development

The rat renal nerves during development

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