Biomaterials denoting self‐healing and versatile structural integrity are highly curious in the biomedicine segment. The injectable and/or printable 3D (3 dimensional) printing technology was explored in a few decades back, which can alter their dimensions temporarily under shear stress, showing potential healing/recovery tendency with patient‐specific intervention towards the development of personalized medicine. Thus, self‐healing injectable hydrogels (IHs) are stunning towards developing a paradigm for tissue regeneration. The article comprises the designing of IHs, rheological characterization and stability, several benchmark consequences for self‐healing IHs, their translation into tissue regeneration of specific types, applications of IHs in biomedical such as anticancer and immunomodulation, wound healing and tissue/bone regeneration, antimicrobial potentials, drugs, gene and vaccine delivery, ocular delivery, 3D printing, cosmeceuticals and photothermal therapy as well as in other allied avenues like agriculture, aerospace, electronic/electrical industries, coating approaches, patents associated with therapeutic/non‐therapeutic avenues and numerous futuristic challenges and solutions.This article is protected by copyright. All rights reserved