A static magnetic field inhibits the expression of platelet-derived growth factor-AA in human oral squamous cell carcinoma

Obayashi-Ishii, Miho; Saito, S; Omagari, Daisuke; Asano, Masaharu; Ishigami, Tomohiko

doi:10.2334/josnusd.17-0380

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Different results were obtained by Obayashi-Ishii M et al [45]. They observed an inhibitory effect of a 150 mT static magnetic field on PDGF-AA secretion in human oral squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 77%

The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets

Cecerska-Heryć,

Goszka,

Gliźniewicz

et al. 2024

IJMS

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Platelets are actively involved in tissue injury site regeneration by producing a wide spectrum of platelet-derived growth factors such as PDGF (platelet-derived growth factor), IGF-1 (insulin-like growth factor), TGF-β1 (transforming growth factor β), FGF (fibroblast growth factor), etc. A rotating magnetic field (RMF) can regulate biological functions, including reduction or induction regarding inflammatory processes, cell differentiation, and gene expression, to determine the effect of an RMF on the regenerative potential of platelets. The study group consisted of 30 healthy female and male volunteers (n = 15), from which plasma was collected. A portion of the plasma was extracted and treated as an internal control group. Subsequent doses of plasma were exposed to RMF at different frequencies (25 and 50 Hz) for 1 and 3 h. Then, the concentrations of growth factors (IGF-1, PDGF-BB, TGF-β1, and FGF-1) were determined in the obtained material by the ELISA method. There were statistically significant differences in the PDGF-BB, TGF-β1, IGF-1, and FGF-1 concentrations between the analyzed groups. The highest concentration of PDGF-BB was observed in the samples placed in RMF for 1 h at 25 Hz. For TGF-β1, the highest concentrations were obtained in the samples exposed to RMF for 3 h at 25 Hz and 1 h at 50 Hz. The highest concentrations of IGF-1 and FGF-1 were shown in plasma placed in RMF for 3 h at 25 Hz. An RMF may increase the regenerative potential of platelets. It was noted that female platelets may respond more strongly to RMF than male platelets.

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Section: Discussionmentioning

confidence: 77%

The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets

Cecerska-Heryć,

Goszka,

Gliźniewicz

et al. 2024

IJMS

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“…An augmented M−CSF is associated with increased infiltration of tumor-associated macrophages and reduces survival rate in oral cancer ( Guo et al, 2020 ). PDGA-AA has shown to be a VEGF regulator augmenting angiogenesis in oral cancer tissue, potentiating metastasis ( Obayashi-Ishii et al, 2018 ). PDGA-BB has also been shown to have a strong correlation with nodal metastasis and poor survival outcome in oral cancer ( Lin et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Assessing the effect of human dental pulp mesenchymal stem cell secretome on human oral, breast, and melanoma cancer cell lines

Raj

Kheur

Bhonde

et al. 2021

Saudi Journal of Biological Sciences

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Background The secretome of the dental pulp mesenchymal stem cells (DPMSCS-S) have an array of regenerative potential and could aid in the rehabilitation of cancer patients post-therapeutic interventions, although caution is required as DPMSC-S have shown to augment prostate cancer cells. Thus, it is vital to assess if these pro-carcinogenic effects extend to other cancer types. Objective To assess if DPMSC-S has any pro-carcinogenic effect on oral cancer, breast cancer, and melanoma cell lines. Materials and methods Conditioned media obtained from the isolated and characterized DPMSC (DPMSC-CM) were profiled using bead-based multiplex assay. AW13515 (oral cancer), MDA-MB-231 (breast cancer), and A-375 (melanoma) cell lines were exposed to 20%, 50%, and 100% DPMSC-CM for 24, 48, and 72 h. DPMSC-CM effect on the cancer cell properties and secretome were assessed. Results DPMSC-CM augmented invasion, adhesion, multi-drug resistance, DNA repair, and mitochondrial repair in AW13516 through upregulation of growth factors Ang-2, EGF, M−CSF, PDGF-AA, PDGF-BB, pro-inflammatory cytokines TNF-α, IL-2, downregulation of anti-inflammatory cytokine TGF-β1, and pro-inflammatory cytokine IL-4. In MDA-MB-231, invasion, and multi-drug resistance were augmented through upregulation of growth factors EGF, EPO, G-CSF, HGF, M−CSF, PDGF-AA, and pro-inflammatory cytokine TNF-α, CXCL10, IL-12p70. EMT, invasion, migration, and adhesion were augmented in A-375 through upregulation of growth factors Ang-2, EGF, PDGF-BB, TGF-α, pro-inflammatory cytokines TNF-α, and IL-17A. Conclusion DPMSC-CM can augment the carcinogenic properties of oral cancer, breast cancer, and melanoma cells, further animal model studies are required to validate our in-vitro findings.

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A static magnetic field inhibits the expression of platelet-derived growth factor-AA in human oral squamous cell carcinoma

Cited by 2 publications

References 28 publications

The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets

The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets

Assessing the effect of human dental pulp mesenchymal stem cell secretome on human oral, breast, and melanoma cancer cell lines

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