A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients

Ingredients in Commercially Available Mouthwashes

“…PEG-60, on the other hand, is a macromolecule greater than 1000 kDa in weight and is a water-insoluble material that has shown low oral acute toxicity in studies. 88 Although polysorbate 20, a flavouring and solubilisation agent found in mouthwashes, has an absorption-enhancing effect in the gastrointestinal region in patients with difficult intestinal absorption of oral medication, 89 it has been discovered that it can occasionally induce toxic effects due to increase intestinal permeability. 90 Developments in the field of nanotechnology and polymers have led to the emergence of more specific target-oriented polymers such as poloxamer, which can exhibit evoked potentials and biological behaviour and can be used in drug delivery systems.…”