A stilbene from the heartwood of Maclura pomifera: Note

Djapic, Nina; Ďjarmati, Z.; Filip, Snežana; Jankov, Mirko

doi:10.2298/jsc0303235d

Cited by 14 publications

(6 citation statements)

References 5 publications

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“…The infrared spectrum of compound 1 also matched that of oxyresveratrol (data not shown). The 1 H-NMR and 13 C-NMR spectral patterns of compound 1 were in good agreement with those of standard oxyresveratrol and with those reported in the literature (data not shown) (Djapic et al 2003;Soekamtoa et al 2005). The results suggest that compound 1 is oxyresveratrol.…”

Section: Oxyresvertrol Was Identified From Mb Extractsupporting

confidence: 86%

FOXO3a Activation by oxyresveratrol ofMorus bombyciskoidzumi extract mediates antioxidant activity

Heo

Kim

Lee

et al. 2016

Animal Cells and Systems

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Although Morus bombycis koidzumi (MB) extract has been reported to have antioxidant activity, the mechanism underlying its antioxidant activity has not been elucidated. In this report, we showed that FOXO3a was activated by MB extract. FOXO3a is a transcription factor that is involved in various biological functions such as cell cycle control, apoptosis, DNA repair, and reactive oxygen species (ROS) detoxification. Protein levels of FOXO3a and MnSOD, target gene of FOXO3a were increased by the MB extract. The ROS level was decreased by the MB extract in human embryonic fibroblast (HEF) cells. Among components of the MB extract, oxyresveratrol (2 ′ ,4 ′ ,3,5-tetrahydroxystilbene) was identified and turned out to activate FOXO3a. The protein level of FOXO3a was increased by oxyresveratrol. Promoter activities of target genes of FOXO3a such as MnSOD, p27, and GADD45 were activated by oxyresveratrol. The ROS level was decreased by oxyresveratrol in HEF cells in a dose-dependent manner. However, the ROS level was elevated in HEF cells when FOXO3a was knocked down by si-FOXO3a, while overexpression of wt-FOXO3a decreased the cellular ROS level, indicating that antioxidant activity by oxyresveratrol is FOXO3a-dependent. These results indicate that oxyresveratrol of MB extract mediates an antioxidant activity through upregulation of MnSOD by FOXO3a activation. ARTICLE HISTORY

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Section: Oxyresvertrol Was Identified From Mb Extractsupporting

confidence: 86%

FOXO3a Activation by oxyresveratrol ofMorus bombyciskoidzumi extract mediates antioxidant activity

Heo

Kim

Lee

et al. 2016

Animal Cells and Systems

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“…Solvents A and B were 0.05% TFA/H 2 O and 0.05% TFA/CAN, respectively. The identity of oxyresveratrol with a purity of 97% from M. alba was confirmed by comparing its spectroscopic data with previously published data [45,46]. …”

Section: Methodssupporting

confidence: 57%

“…Peak 1 was isolated from the M. alba extract and identified as oxyresveratrol as shown in Figure 3. The NMR data (Additional file 1: Table S1), UV spectra data (Additional file 1: Figure S1A) and MS data (Additional file 1: Figure S1B) of oxyresveratrol in the study were analyzed and confirmed with those described elsewhere [45,46]. …”

Section: Resultsmentioning

confidence: 59%

Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling

Chen

Tien

Chen

et al. 2013

BMC Complement Altern Med

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BackgroundMorus alba has long been used in traditional Chinese medicine to treat inflammatory diseases; however, the scientific basis for such usage and the mechanism of action are not well understood. This study investigated the action of M. alba on leukocyte migration, one key step in inflammation.MethodsGas chromatography-mass spectrometry (GC-MS) and cluster analyses of supercritical CO2 extracts of three Morus species were performed for chemotaxonomy-aided plant authentication. Phytochemistry and CXCR4-mediated chemotaxis assays were used to characterize the chemical and biological properties of M. alba and its active compound, oxyresveratrol. fluorescence-activated cell sorting (FACS) and Western blot analyses were conducted to determine the mode of action of oxyresveratrol.ResultsChemotaxonomy was used to help authenticate M. alba. Chemotaxis-based isolation identified oxyresveratrol as an active component in M. alba. Phytochemical and chemotaxis assays showed that the crude extract, ethyl acetate fraction and oxyresveratrol from M. alba suppressed cell migration of Jurkat T cells in response to SDF-1. Mechanistic study indicated that oxyresveratrol diminished CXCR4-mediated T-cell migration via inhibition of the MEK/ERK signaling cascade.ConclusionsA combination of GC-MS and cluster analysis techniques are applicable for authentication of the Morus species. Anti-inflammatory benefits of M. alba and its active compound, oxyresveratrol, may involve the inhibition of CXCR-4-mediated chemotaxis and MEK/ERK pathway in T and other immune cells.

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“…By comparing their physical and spectroscopic data with those reported in the literature or analyzing their 2D-NMR spectral data, the known compounds ( Figure 1) were identified as moracin M (2) [12], moracin P (3) [13], resveratrol (4) [14], oxyresveratrol (5) [15], oxyresvera- [17], mongolicon F (8) [18], guangsangon J (9) [19], b-daucosterol (10) [20], and b-sitosterol (11) [20].…”

Section: Resultsmentioning

confidence: 99%

New 2-arylbenzofuran metabolite from cell cultures ofMorus alba

Zhang

Tao

et al. 2015

Journal of Asian Natural Products Research

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A new 2-arylbenzofuran compound, 5-dehydroxy-moracin U (1), along with 10 known compounds (2-11), were isolated from cell cultures of Morus alba. Their structures were elucidated on the basis of extensive spectroscopic analyses. The anti-inflammatory activity assay of 1-8 showed that 2 and 8 exhibited significant inhibitory effect on LPS-induced NO production with the values of 76.4% and 98.7% at 10(- 5) M, respectively.

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A stilbene from the heartwood of Maclura pomifera: Note

Abstract: Dried heartwood powder of Maclura pomifera, Moraceae, was extracted with acetone. Silica gel column chromatography (CC) of the crude extract yielded 2',3',4',5'-tetrahydroxystilbene (oxyresveratrol).

Cited by 14 publications

References 5 publications

FOXO3a Activation by oxyresveratrol ofMorus bombyciskoidzumi extract mediates antioxidant activity

FOXO3a Activation by oxyresveratrol ofMorus bombyciskoidzumi extract mediates antioxidant activity

Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling

New 2-arylbenzofuran metabolite from cell cultures ofMorus alba

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