A stimuli-responsive coaxial nanofilm for burst release

Responsive Biomaterials: Advances in Materials Based on Shape‐Memory Polymers

“…[23] Alternatively, shape-memory coatings for model drug-loaded hydrogels have been demonstrated to be effective for inducing hydrogel-medicated drug delivery resulting from the stress induced by the shape-memory outer layer following an increase in temperature. [24] Hydration-responsive SMP-based materials enable the delivery of drugs and potentially cells to a precise location inside the body by minimally invasive surgical procedures. For example, xerogels based on composites of bacterial nanocellulose with various hydrophilic additives (e.g., glucose, sucrose, lactose, poly(ethylene glycol), sodium chloride) have been shown to respond to rehydration by releasing a model low molecular weight drug azorubine over a period of hours.…”

Multistructured Nanogel‐Based Networks Formed from Interfacial Redox Polymerizations for Modulating Small Molecule Release

“…While drug‐releasing coatings have been prepared from a variety of methods, an opportunity exists for applying a redox‐based interfacial polymerization toward developing multilayered polymers for controlled release. Hydrogels have been frequently explored for releasing drugs and therapeutic biomolecules such as peptides and proteins, and the previously described work on redox‐initiated multilayered poly(ethylene glycol) networks has extensively characterized the coating reaction.…”

“…[9,10] Using similar principles to coating and layer formation on bulk substrates, coatings on micro and nanoparticles have also been generated via redox initiated polymerization, [11,12] reversible addition-fragmentation chain-transfer (RAFT) polymerization techniques, [13] and layer-by-layer processing. [2,14] While drug-releasing coatings have been prepared from a variety of methods, [15][16][17][18][19] an opportunity exists for applying a redox-based interfacial polymerization toward developing multilayered polymers for controlled release. Hydrogels have been frequently explored for releasing drugs and therapeutic biomole cules such as peptides and proteins, [20][21][22][23][24] and the previously described work on redox-initiated multilayered poly(ethylene glycol) networks has extensively characterized the coating reaction.…”

Chemical Vapor Deposition for Solvent‐Free Polymerization at Surfaces

“…Reproduced with permission. [ 39 ] Copyright 2011, The Royal Society of Chemistry. b) Release of fl uorescein from a hydrogel layer with a mesh size of 2 nm is evidenced by an emission peak at 490 nm; no release is observed from a hydrogel with a mesh size of 0.5 nm.…”

“…[ 39 ] To fabricate these devices, the pores of anodized aluminum oxide membranes were sequentially coated with conformal layers of shape memory polymer and a hydrogel core. Hydrogel materials, such as pHEMA, swell in response to external stimuli, including heat and pH.…”