A stochastic model simulating paratuberculosis in a dairy herd

Kudahl, Anne Braad; Østergaard, Søren Dinesen; Sørensen, Jan Tind; Nielsen, Søren Saxmose

doi:10.1016/j.prevetmed.2006.05.015

Cited by 73 publications

(99 citation statements)

References 30 publications

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“…Kudahl et al (2008) evaluated the potential long-term effects of the riskbased program compared with non-risk-based "classical disease control measures" using the PTB-Simherd herd-simulation model (Kudahl et al, 2007). Those authors observed that the results obtained from the riskbased control strategies were very efficient in reducing the prevalence of paratuberculosis in cattle using less labor than non-risk-based control strategies (such as optimized management of all cows).…”

Section: Risk-based Strategies For the Control Of Paratuberculosismentioning

confidence: 99%

Invited review: The economic impact and control of paratuberculosis in cattle

Garcia

Shalloo

2015

Journal of Dairy Science

189

124

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Paratuberculosis (also called Johne's disease) is a chronic disease caused by Mycobacterium avium ssp. paratuberculosis (MAP) that affects ruminants and other animals. The epidemiology of paratuberculosis is complex and the clinical manifestations and economic impact of the disease in cattle can be variable depending on factors such as herd management, age, infection dose, and disease prevalence, among others. Additionally, considerable challenges are faced in the control of paratuberculosis in cattle, such as the lack of accurate and reliable diagnostic tests. Nevertheless, efforts are directed toward the control of this disease because it can cause substantial economic losses to the cattle industry mainly due to increased premature culling, replacement costs, decreased milk yield, reduced feed conversion efficiency, fertility problems, reduced slaughter values, and increased susceptibility to other diseases or conditions. The variability and uncertainty surrounding the estimations of paratuberculosis prevalence and impact influence the design, implementation, and efficiency of control programs in diverse areas of the world. This review covers important aspects of the economic impact and control of paratuberculosis, including challenges related to disease detection, estimations of the prevalence and economic effects of the disease, and the implementation of control programs. The control of paratuberculosis can improve animal health and welfare, increase productivity, reduce potential market problems, and increase overall business profitability. The benefits that can derive from the control of paratuberculosis need to be communicated to all industry stakeholders to promote the implementation of control programs. Moreover, if the suspected link between Johne's disease in ruminants and Crohn's disease in humans was established, significant economic losses could be expected, particularly for the dairy industry, making the control of this disease a priority across dairy industries internationally.

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Section: Risk-based Strategies For the Control Of Paratuberculosismentioning

confidence: 99%

Invited review: The economic impact and control of paratuberculosis in cattle

Garcia

Shalloo

2015

Journal of Dairy Science

189

124

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“…Mathematical models for JD in dairy cattle have been developed to understand MAP transmission dynamics and to predict the effectiveness of recommended control programs (Kudahl et al, 2007;Lu et al, 2008Lu et al, , 2010Mitchell et al, 2008;Marce et al, 2010). Mathematical models have the advantage of being able to study infectious dynamics under a wide range of scenarios, without necessarily having to obtain perfect data for all these scenarios.…”

Section: Introductionmentioning

confidence: 99%

Back to the real world: Connecting models with data

Mitchell

Whitlock

Gröhn

et al. 2015

Preventive Veterinary Medicine

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“…By using the Ziehl-Neelsen staining method (ZN-test), acid-alcohol resistant bacteria are observed in feces smears and at the end portions of the small intestine, however, serum-ELISA has been referred as superior to the ZN-test to confirm the presumptive diagnosis of clinical paratuberculosis in cattle (Weber et al, 2009). Subclinical cases can be diagnosed by isolating the bacteria from the feces, serological tests, or allergy tests (Lilenbaum et al, 2007). Hendrick et al (2005) found that serum-and milk-ELISAs may be potentially useful and convenient methods in detecting subclinical paratuberculosis in lactating dairy cattle, with sensitivities of 73.6% (95% CI = 61.9-83.3%) and 61.1% (95% CI = 48.9-72.4%), and specificities of 87.5% (95% CI = 84.7-90.0%) and 94.7% (95% CI = 92.6-96.3%), respectively, compared to fecal culture.…”

Section: Introductionmentioning

confidence: 99%