A straightforward and sustainable one-pot, four-component synthesis of rhodanine derivatives

Discovery of Novel Sulfonamide‐Based 5‐Arylidenerhodanines as Effective Carbonic Anhydrase (II) Inhibitors: Microwave‐Assisted and Ultrasound‐Assisted One‐Pot Four‐Component Synthesis, Molecular Docking, and Anti‐CA II Screening Studies

“…For his purpose, a great deal of MW‐based techniques are reported , while only one straightforward US‐mediated synthesis for rhodanines was reported . The based catalyst Knoevenagel reaction leading to the condensation of rhodanines with aldehydes was carried out in separate steps . In this regard, many different catalysts, reaction conditions, and solvents were used.…”

One‐pot, Four‐Component Green Synthesis, Carbonic Anhydrase II Inhibition and Docking Studies of 5‐Arylidenerhodanines

“…Both in multi‐step and one pot multicomponent reactions, the synthesis of 5‐arylidenerhodanines is generally based on a base catalyzed Knoevenagel reaction of the corresponding N ‐substituted rhodanines which are obtained from one‐pot three component condensation of amine, chloroacetic acid and carbon disulfide or bis(carboxymethyl)trithiocarbonate reagent with aromatic or aliphatic aldehydes . For this step, numerous microwave‐based techniques have been developed, while to our knowledge, only one straightforward ultrasound irradiated synthesis of these compounds has been described …”

“…Therefore, there is a need to develop mild and green methods for the synthesis of these key building blocks available for drug discovery and related settings. Although considerable efforts have been devoted for the development of ecofriendly and economic procedures for the preparation of arylidene rhodanines, the one‐pot multicomponent synthesis of these synthons has remained as a very challenging issue because of some drawbacks such as the employment of a phosphine catalyst or chromatographic separation, which could be an issue with respect to work‐up …”

A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process

“…Multicomponent processes are undoubtedly one of the most efficient approaches to forming several important motifs in modern organic synthesis and pharmaceutical synthesis [24][25][26]. For example, rhodanines have been successfully synthesized through multicomponent processes [27][28][29][30][31][32][33]. However, almost all known methods involving multicomponent reactions cannot achieve the synthesis of 5-unsubstituted rhodanines.…”