A Straightforward Synthesis of Emericellamide A Using Matteson’s Homologation Approach

Abstract

The Matteson homologation is the perfect approach for the synthesis of polyketide–peptide natural products such as the emericellamides. In only 4 steps the polyketide fragment with three stereogenic centers can be obtained as a single stereoisomer. The peptide fragment is easily available via solid-phase peptide synthesis.