A strained ring for stereoselective synthesis

Jankovic, Christian L; West, F. G.

doi:10.1126/science.ade7122

Science

2023

DOI: 10.1126/science.ade7122

|View full text |Cite

A strained ring for stereoselective synthesis

Christian L Jankovic

F. G. West

Abstract: The spring-loaded tension of a cyclic allene expedites synthesis of a natural product

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Copper-Catalyzed Asymmetric Yne-Allylic Substitution Using Electron-Rich Arenes

Luo,

Niu,

Gong

et al. 2024

ACS Catal.

View full text Add to dashboard Cite

Remote stereocontrol in transition-metal catalysis is a challenging but interesting research topic. In this work, we achieved copper-catalyzed asymmetric yne-allylic substitution using electron-rich arenes and acyclic carbonates through remote enantioselectivity control. The reaction delivers a variety of enantioenriched products that contain a diverse set of valuable moieties, such as conjugated enynes, indoles, indolizines, allenes, and dihydrofurans, which are widely used in organic synthesis and act as key units in bioactive molecules and natural products. The synthetic value of this protocol has been demonstrated in a series of further transformations, and mechanistic studies have been conducted to gain more insight into the reaction.

show abstract

Copper-Catalyzed Asymmetric Yne-Allylic Substitution Using Electron-Rich Arenes

Luo,

Niu,

Gong

et al. 2024

ACS Catal.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A strained ring for stereoselective synthesis

Abstract: The spring-loaded tension of a cyclic allene expedites synthesis of a natural product

Cited by 1 publication

References 12 publications

Copper-Catalyzed Asymmetric Yne-Allylic Substitution Using Electron-Rich Arenes

Copper-Catalyzed Asymmetric Yne-Allylic Substitution Using Electron-Rich Arenes

Contact Info

Product

Resources

About