A Strange Case of Phyllodes Tumor Detected Using 18F-FDG PET/CT in an Adolescent Patient Affected by Hodgkin Lymphoma: A Possible Pitfall

Cucinotta, Mariapaola; Quartuccio, Natale; Coppolino, Pietro; Delfa, Vincenzo La; Bianchi, Maurizio; Cistaro, Angelina

doi:10.1016/j.clml.2014.06.106

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…However, malignant transformation cannot be excluded. Multiple conditions, such as osteosarcoma, neurofibromatosis and lymphoma, can predispose the child to malignant PT [ 12 , 13 , 14 ]. The same findings can be true for the patients with genetic mutations associated with an increased risk of cancer [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Inflamed Phylloides Tumour in a Girl: A Challenging Diagnosis in Paediatric Breast Lesions

Testa

Salvatori

Prestipino

et al. 2018

IJERPH

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Introduction: Phylloides tumours (PTs) are rare fibroepithelial neoplasms that account for 0.3–0.9% of all breast tumours. These tumours typically occur in women aged 30–70 years. The occurrence of these tumours in older children and adolescents poses particular diagnostic and therapeutic problems. However, early diagnosis is mandatory because although most of the cases of PTs in children are benign, the borderline and malignant cases with potential negative outcomes cannot be excluded. Case presentation: A 12-year-old girl presented at the Paediatric Emergency Department for hyperaemia and warmth of the left breast that occurred a few days prior without fever. The girl experienced menarche 8 months previously. She experienced no previous trauma and she had no family history of breast cancer. On physical examination, the left breast was painful, enlarged and tender. The overlying skin was erythematous and warm. A breast ultrasonography (US) revealed a large mass with features of an abscess, including a hyperechoic wall, scattered internal echoes and hypoechoic peripheral lacunae of apparent colliquative nature. After 4 days of unsuccessful antibiotic therapy, surgical drainage was performed due to the suspicion of a mammary abscess. At the surgical incision site, the lesion was not-well circumscribed and lacked a capsule. In addition, purulent material was not detected. Histological examination revealed that the tissue alterations were compatible with benign PT. With this diagnosis, the girl underwent definitive surgical removal of the lesion. The postoperative period passed without negative events. An US performed 6 months later revealed that no new mass was present at this time, suggesting no recurrence of the tumour. Conclusion: This case shows that in the presence of a clinical picture suggesting the inflammation of the breast in adolescent females, PT should be considered as a possible diagnosis and US-guided core biopsy should be considered to confirm this suspicion. Thereafter, when surgical excision is performed, particular attention must be paid to both the preservation of all the normal breast parenchyma and future aesthetic problems.

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Section: Discussionmentioning

confidence: 99%

Inflamed Phylloides Tumour in a Girl: A Challenging Diagnosis in Paediatric Breast Lesions

Testa

Salvatori

Prestipino

et al. 2018

IJERPH

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“…Thorough literature searches found the combination of this rare tumor after successful treatment for HL reported in only one case in Morocco . A concurrent phyllodes tumor was detected in an adolescent as part of her 18 F‐FDG PET/CT imaging during therapy for Hodgkin lymphoma, perhaps suggesting there could be a role for 18F‐FDG PET/CT in the prediction of local recurrence or distal metastases of malignant phyllodes lesions . Widening the literature search to include phyllodes tumor after radiation for any kind of malignancy yielded two more cases .…”

Section: Discussionmentioning

confidence: 99%

“…18 A concurrent phyllodes tumor was detected in an adolescent as part of her 18 F-FDG PET/CT imaging during therapy for Hodgkin lymphoma, perhaps suggesting there could be a role for 18F-FDG PET/CT in the prediction of local recurrence or distal metastases of malignant phyllodes lesions. 19 Widening the literature search to include phyllodes tumor after radiation for any kind of malignancy yielded two more cases. 20,21 These studies in combination suggest that the malignant transformation of a fibroadenoma or the development of a PT as a second cancer must be considered in all patients who have received chest radiation for any cause.…”

Section: Discussionmentioning

confidence: 99%