Scholarship on the fourteen Augustan regions of Rome has tended to focus on their political and topographical significance. As a result, evidence for their social meaning and their impact on the mindsets and practices of the city's administrators and rulers has been under-exploited. This article seeks to address this lacuna. It begins by reviewing the history of Rome's regions and asking how and where the boundaries of the Augustan regions were recorded, before moving on to consider the impact of the regions on the Romans’ understanding and experiences of their city. This includes examining the evidence for bottom-up social identification with the regions, despite their top-down original creation. The paper also looks at the administrators who worked with the regions (regional magistrates and the food, water and fire services), arguing that the conceptual framework which the regions provided began to shape their working practices. Finally, it demonstrates the existence of a rhetoric of consistent provision across all fourteen regions, propagated especially by the emperors. The findings across all of these areas reveal that it is essential to take the regions and their impact into account when attempting to understand the topography of the city and the lives of its inhabitants.