A Strategic Review on Carbon Quantum Dots for Cancer-Diagnostics and Treatment

Naik, Kaustubh; Chaudhary, Shilpi; Ye, Lei; Parmar, Avanish Singh

doi:10.3389/fbioe.2022.882100

Cited by 54 publications

(26 citation statements)

References 146 publications

(171 reference statements)

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“…Natural plant-derived CDs, a major precursor of green biomass with rich chemical composition, have aroused wide attention for green sources and remarkable bioactivities [ 21 , 48 ]. Nowadays, bottom-up methods have aroused the interest of scientists for their double advantage of being straightforward and economical [ 27 , 49 ], such as hydrothermal method and pyrolysis method.…”

Section: Discussionmentioning

confidence: 99%

Ultrasmall and highly biocompatible carbon dots derived from natural plant with amelioration against acute kidney injury

Wang

Yang

et al. 2023

J Nanobiotechnol

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Background Acute kidney injury (AKI) refers to a tricky clinical disease, known by its high morbidity and mortality, with no real specific medicine for AKI. The carbonization product from Pollen Typhae (i.e., Pu-huang in China) has been extensively employed in clinic, and it is capable of relieving the renal damage and other diseases in China since acient times. Results Inspired by the carbonization process of Traditional Chinese Medicine (TCM), a novel species of carbon dots derived from Pollen Typhae (PT-CDs) was separated and then collected using a one-pot pyrolysis method. The as-prepared PT-CDs (4.85 ± 2.06 nm) with negative charge and abundant oxygenated groups exhibited high solubility, and they were stable in water. Moreover, the rhabdomyolysis (RM)-induced AKI rat model was used, and it was first demonstrated that PT-CDs had significant activity in improving the level of BUN and CRE, urine volume and kidney index, and histopathological morphology in RM-induced AKI rats. It is noteworthy that interventions of PT-CDs significantly reduced degree of inflammatory reaction and oxidative stress, which may be correlated with the basial potential mechanism of anti-AKI activities. Furthermore, cytotoxicity assay and biosafety evaluation exhibited high biocompatibility of PT-CDs. Conclusion This study offers a novel relieving strategy for AKI based on PT-CDs and suggests its potential to be a related candidate for clinical applications. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Ultrasmall and highly biocompatible carbon dots derived from natural plant with amelioration against acute kidney injury

Wang

Yang

et al. 2023

J Nanobiotechnol

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“…This enables them to be precisely investigated through various characterization techniques and analysis protocols for their diverse applications. 50 Plant derived CQDs are characterized through microscopy, spectroscopy, diffraction, and mass spectrometry based on fundamental techniques. The involved techniques and the obtained information from different characterization techniques are tabulated in Table 2.…”

Section: Characterization Of Cqdsmentioning

confidence: 99%

A review on plant derived carbon quantum dots for bio-imaging

Maurya¹,

Saikia²,

Navaneethan³

et al. 2023

Mater. Adv.

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“…The most notable property of these nanoparticles is their luminous nature. As a result, CQDs have been extensively utilised in the domains of photocatalysis, 17 solar technology, 18 ion detection, 19 bioimaging, 20 and light-emitting devices. 21 There are many ways to make CQDs; some of the more well-known routes include electrochemical oxidation, 22 microwave irradiation, 23 laser ablation, 24 hot injection, 25 hydrothermal, 26 and pyrolysis.…”

Section: Introductionmentioning

confidence: 99%