This article traces the trajectory of party Euroscepticism in Greece drawing upon theories of issue competition. It demonstrates that the economic dimension of the multiple crises facing the EU contributed to a Eurosceptic shift in public opinion; the electoral success of Eurosceptic parties; new parties populating the Europhile end of the spectrum; and the formation of a coalition government united not by ideological affinity but by a common Eurosceptic and anti-austerity agenda. Mainstream parties maintained their pro-EU agendas and challenger parties offered both pro-and anti-EU policy options to the electorate. The prospect of power resulted in the progressive softening of Euroscepticism among challenger parties. EU issue salience was relatively high across the party system and remained so during the crisis. Although Greek parties justified their pro-and anti-EU attitudes using a number of frames, economic arguments were prevalent at the height of the crisis, and challenger parties of the left intensified their claims of the EU interfering in national politics. The findings have implications for our understanding of the evolving nature of Euroscepticism and the ways in which it may feature in domestic party politics.