A Strategy for Hospital Pharmacists to Control Antimicrobial Resistance (AMR) in Japan

Hamada, Yukihiro; Ebihara, Fumiya; Kikuchi, Ken

doi:10.3390/antibiotics10111284

Cited by 6 publications

(2 citation statements)

References 66 publications

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“…Clinical pharmacist intervention has been shown to be effective in enhancing appropriate use of antibiotics and reducing their toxicity, which may improve patient care. Moreover these had a positive impact not only on the clinical, but on financial outcomes [131][132][133][134][135].…”

Section: Methods Of Reducing the Frequency And Severity Of Antibiotic...mentioning

confidence: 99%

Antibiotics and the Nervous System—Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?

2021

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Antibiotics as antibacterial drugs have saved many lives, but have also become a victim of their own success. Their widespread abuse reduces their anti-infective effectiveness and causes the development of bacterial resistance. Moreover, irrational antibiotic therapy contributes to gastrointestinal dysbiosis, that increases the risk of the development of many diseases, including neurological and psychiatric. One of the potential options for restoring homeostasis is the use of oral antibiotics that are poorly absorbed from the gastrointestinal tract (e.g., rifaximin alfa). Thus, antibiotic therapy may exert neurological or psychiatric adverse drug reactions which are often considered to be overlooked and undervalued issues. Drug-induced neurotoxicity is mostly observed after beta-lactams and quinolones. Penicillin may produce a wide range of neurological dysfunctions, including encephalopathy, behavioral changes, myoclonus or seizures. Their pathomechanism results from the disturbances of gamma-aminobutyric acid-GABA transmission (due to the molecular similarities between the structure of the β-lactam ring and GABA molecule) and impairment of the functioning of benzodiazepine receptors (BZD). However, on the other hand, antibiotics have also been studied for their neuroprotective properties in the treatment of neurodegenerative and neuroinflammatory processes (e.g., Alzheimer’s or Parkinson’s diseases). Antibiotics may, therefore, become promising elements of multi-targeted therapy for these entities.

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Section: Methods Of Reducing the Frequency And Severity Of Antibiotic...mentioning

confidence: 99%

Antibiotics and the Nervous System—Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?

2021

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“…Adapted from the literature: A strategy for hospital pharmacists to control antimicrobial resistance (AMR) in Japan. Antibiotics 10: 1284, 202115) …”

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confidence: 99%

Antifungal Stewardship Task Shifting Required of Pharmacists

Ebihara

Maruyama

Kikuchi

et al. 2022

Medical Mycology Journal

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Similar to antimicrobial stewardship, the concept of antifungal stewardship (AFS) has also received attention. AFS outcomes include reduced healthcare costs, avoidance of adverse events, and increased implementation of therapeutic drug monitoring (TDM). Several processes and outcome measures have recently been reported for implementing AFS and evaluating its effectiveness in healthcare institutions. This review focuses on our AFS efforts to standardize treatment using a template for pharmacist-led patient intervention for candidemia and to evaluate TDM dosage adequacy rates for voriconazole. The importance of "task shifting", in which the physician's work is transferred or shared with pharmacists and other co-medical staff to alleviate concentration of physician workload, has also been advocated. This review focuses on how pharmacists are involved in AFS.

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Inactivation of antibiotic-resistant bacteria in hospital wastewater by ozone-based advanced water treatment processes

Azuma,

Usui,

Hayashi

2024

Science of The Total Environment

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A Strategy for Hospital Pharmacists to Control Antimicrobial Resistance (AMR) in Japan

Cited by 6 publications

References 66 publications

Antibiotics and the Nervous System—Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?

Antibiotics and the Nervous System—Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?

Antifungal Stewardship Task Shifting Required of Pharmacists

Inactivation of antibiotic-resistant bacteria in hospital wastewater by ozone-based advanced water treatment processes

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