A strategy to passively reduce neuroinflammation surrounding devices implanted chronically in brain tissue by manipulating device surface permeability

Skousen, John L.; Bridge, M.J.; Tresco, Patrick A.

doi:10.1016/j.biomaterials.2014.08.039

Cited by 55 publications

(67 citation statements)

References 49 publications

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“…For example, injectable wireless electronics can carry out electrical recordings, optical stimulation, temperature sensing and photodetection 175 . Also, the immune response can be mitigated by decreasing implant volume and by increasing surface permeability or porosity, facilitating the dispersion of inflammatory cytokines and preventing their accumulation, as has been achieved with porous coatings 187 and web-like mesh electronics 188–190 . Although advancements in material-based strategies to improve the neuron/electrode interface continue, there is a need to pursue basic-science studies to identify guiding biological principles for improved device design.…”

Section: Glial-activation Challenges and Design Considerationsmentioning

confidence: 99%

“…Mediation of these pathways may improve device function; for instance, knock-out of caspase-1, which activates IL-1β, has demonstrated significant improvement to long-term functional recordings 82 . For smaller feature sizes, improvements in gliosis are broadly associated with reduced injury-related inflammation and BBB permeability along with reduced micromotion-related tissue strain 187 . Still, further details on the relationship between the material characteristics of an electrode and the inflammatory/molecular effects on reactive glia are needed to establish guiding principles to design fully integrated devices (including intervention strategies and their temporal influence).…”

Section: Glial-activation Challenges and Design Considerationsmentioning

confidence: 99%

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Glial responses to implanted electrodes in the brain

et al. 2017

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The use of implants that can electrically stimulate or record electrophysiological or neurochemical activity in nervous tissue is rapidly expanding. Despite remarkable results in clinical studies and increasing market approvals, the mechanisms underlying the therapeutic effects of neuroprosthetic and neuromodulation devices, as well as their side effects and reasons for their failure, remain poorly understood. A major assumption has been that the signal-generating neurons are the only important target cells of neural-interface technologies. However, recent evidence indicates that the supporting glial cells remodel the structure and function of neuronal networks and are an effector of stimulation-based therapy. Here, we reframe the traditional view of glia as a passive barrier, and discuss their role as an active determinant of the outcomes of device implantation. We also discuss the implications that this has on the development of bioelectronic medical devices.

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Section: Glial-activation Challenges and Design Considerationsmentioning

confidence: 99%

Section: Glial-activation Challenges and Design Considerationsmentioning

confidence: 99%

Glial responses to implanted electrodes in the brain

et al. 2017

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“…Fig. 2b illustrates an example of hydrogel coating for implantable sensors [28]. Brain silicon microelectrodes were coated with alginate hydrogels with two different thicknesses and were implanted into rat brains.…”

Section: Spatial Control Of Hydrogelsmentioning

confidence: 99%

“…(c) Antimicrobial and antifouling activity of silicon rubber coated with polycarbonate/PEF hydrogel. Reproduced with permission from: (a) [27], (b) [28], (c) [20]. …”

Section: Figurementioning

confidence: 99%

Spatially and temporally controlled hydrogels for tissue engineering

Leijten

Seo

Yue

et al. 2017

Materials Science and Engineering: R: Reports

159

129

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Summary Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels’ properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and three-dimensional (3D) bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation. We believe that the development and integration of these techniques will drive the engineering of next-generation engineered tissues.

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“…The study found that the lattice devices resulted in reduced inflammatory response when compared to solid probes. In the second study, diffusion sinks were created on the electrode using a thick hydrogel coating, and significantly reduced foreign body response was also observed [35]. …”

Section: Current Understanding Of Failure Mechanismsmentioning

confidence: 99%

Recent advances in neural electrode–tissue interfaces

Woeppel

Yang

Cui

2017

Current Opinion in Biomedical Engineering

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Neurotechnology is facing an exponential growth in the recent decades. Neural electrode-tissue interface research has been well recognized as an instrumental component of neurotechnology development. While satisfactory long-term performance was demonstrated in some applications, such as cochlear implants and deep brain stimulators, more advanced neural electrode devices requiring higher resolution for single unit recording or microstimulation still face significant challenges in reliability and longevity. In this article, we review the most recent findings that contribute to our current understanding of the sources of poor reliability and longevity in neural recording or stimulation, including the material failure, biological tissue response and the interplay between the two. The newly developed characterization tools are introduced from electrophysiology models, molecular and biochemical analysis, material characterization to live imaging. The effective strategies that have been applied to improve the interface are also highlighted. Finally, we discuss the challenges and opportunities in improving the interface and achieving seamless integration between the implanted electrodes and neural tissue both anatomically and functionally.

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A strategy to passively reduce neuroinflammation surrounding devices implanted chronically in brain tissue by manipulating device surface permeability

Cited by 55 publications

References 49 publications

Glial responses to implanted electrodes in the brain

Glial responses to implanted electrodes in the brain

Spatially and temporally controlled hydrogels for tissue engineering

Recent advances in neural electrode–tissue interfaces

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