A Strong Nucleotypic Effect on the Cell Cycle Regardless of Ploidy Level

Francis, Dennis; Davies, M. S.; Barlow, Peter W.

doi:10.1093/aob/mcn038

Cited by 110 publications

(101 citation statements)

References 89 publications

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“…For example, GS is positively correlated with cell size [5,6]. In addition, Francis et al [7] found a consistent positive relationship between GS and the duration of the cell cycle, which confirmed earlier observations by Bennett [8,9]. Here we test the hypothesis that GS may be a predictor of meristem growth.…”

Section: Introductionsupporting

confidence: 86%

Genome Size Is a Strong Predictor of Root Meristem Growth Rate

et al. 2010

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Variation in genome size (GS) has been linked to several facets of the plant phenotype. Recently it was shown that GS is significantly correlated with cell size and the duration of the cell cycle. Here we test the hypothesis that GS might also be a predictor of apical root meristem growth rate (RMGR). We studied eight species of eudicots with varying GS using time-lapse microscopic image analysis. A significant negative exponential relationship was observed between GS and RMGR. Our results show significantly decreased RMGR for large genome species. This relationship represents a significant consequence of GS expansion in plants and may partly explain why genome sizes tend to be small in eudicots. Interestingly, parasitic plants, which do not rely on root growth as much, often have large genomes.

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Section: Introductionsupporting

confidence: 86%

Genome Size Is a Strong Predictor of Root Meristem Growth Rate

et al. 2010

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“…Cvalue or holoploid genome size (Greilhuber et al [6]), that is, the DNA amount contained in the chromosome complement of an organism, is directly and positively correlated with cell size (Bennett [4], Knight and Beaulieu [7]). Cx-value or monoploid genome size, the DNA amount contained in the single basic chromosome set with chromosome number x, has a strong positive influence on cell cycle duration (Bennett [3,4], Francis et al [8]). This is clearly a simplification inasmuch as cell and nuclear size vary according to cell type and physiological status (Bennett and Rees [9]).…”

Section: Introductionmentioning

confidence: 99%

“…Since the Cx-value of an organism together with the ploidy level determines the C-value, cell cycle duration is also correlated with C-values in global analyses (Francis et al. [8]). Several lines of evidence lend support to the opinion that large genomes are a burden to organisms and restrict their adaptability.…”

Section: Introductionmentioning

confidence: 99%

Heavy Metal Pollution, Selection, and Genome Size: The Species of the Žerjav Study Revisited with Flow Cytometry

Temsch

Ehrendorfer-Schratt

et al. 2010

Journal of Botany

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The Death Valley atŽerjav in northern Slovenia exhibits a gradient of heavy metal pollution in the soil with severe consequences for species richness and composition along this gradient. Recently, a progressive loss of large-genome species in parallel with increasing concentrations of heavy metals has been shown. Here, we have measured the genome size of a near-complete sample of these species with flow cytometry and analysed the correlation of heavy metal pollution with the C-and Cx-values assigned to the test plots. The method of probability analysis was a hypergeometric distribution method. We confirm, on a different methodological basis than previously, that along the pollution gradient, species with high C-and Cx-values are increasingly underrepresented. This lends support to the "large genome constraint hypothesis", predicting that plants with large genomes are at a disadvantage under all aspects of evolution, ecology, and phenotype, because junk DNA imposes a load to the organism.

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“…They made it clear that the amount of DNA present in a genome does affect cell cycle, and ultimately plant growth, regardless of whether or not it was coded. Recently, Francis et al (2008) concluded that the speed of DNA replication was identifi ed as the limiting factor in the cell cycle. Therefore, it follows that individual genome cell cycle differences cause problems of maintaining their synchrony when two or more genomes, with different volumes of DNA, are placed together in a cell.…”

Section: Noted Inmentioning

confidence: 99%