A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography

Zhu, Jinxia; Yang, Zhangwei; Chen, Xiaoli; Liu, Jie; Zheng, Liang; Zhang, Lin; Pi, Jingjiang; Li, Gang; Zhuang, Tao; Liu, Chang; Wang, Yinglu; Liu, Liping; Chan, Paul; Tomlinson, Brian; Liu, Ying; Liu, Zhongmin; Zhang, Yuzhen

doi:10.2147/dmso.s274047

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…However, a recent imaging study indicated that valvular heart disease may alter epicardial adipose tissue phenotype in comparison with adipose tissue in non-valvular disease in patients with atrial fibrillation. 51 We assume that severe valvular disease may influence PCAT transcriptome. In that case, we cannot draw definite conclusions for the pathophysiological interpretation of our results.…”

Section: Discussionmentioning

confidence: 99%

Differences in MicroRNA Expression in Pericoronary Adipose Tissue in Coronary Artery Disease Compared to Severe Valve Dysfunction

et al. 2022

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Pericoronary adipose tissue (PCAT) is a source of microRNAs (miRs) that act as messengers for intercellular communication. We investigated whether the PCAT surrounding significant coronary atherosclerotic lesions shows specific miR expression patterns compared with PCAT surrounding plaque-free segments. We included 49 patients with 3-vessel coronary artery disease (CAD) and 19 patients with severe valvular disease but no CAD, who underwent elective cardiac surgery. The PCAT was harvested from two sites: adjacent to a significant atherosclerotic coronary lesion and from plaque-free segments. miR-133a, miR-21, miR-26b, miR-9, and miR-143 levels in PCAT cells were quantified by real-time reverse transcription polymerase chain reaction (data expressed as arbitrary units). Expression of miR-133, miR-21, and miR-26b in adipose tissue at a site without atherosclerotic lesion was much lower in patients with CAD than in those without CAD (0.82 ± 1.37 vs 1.86 ± 0.52, P < .001, 0.45 ± 1.3 vs 1.51 ± 1.11, P < .001, 0.3 ± 1.25 vs 1.2 ± 0.73, P = .02, respectively). In addition, miR-133, miR-21, and miR-143 in CAD patients showed significantly greater expression in PCAT from atherosclerotic lesion compared with plaque-free segments (1.32 ± 0.96 vs 0.82 ± 0.37 (P = .011), 0.91 ± 1.7 vs 0.3 ± 1.25 (P = .012), 1.2 ± 1.59 vs 0.43 ± 0.54 (P < .001), respectively). Our findings open new perspectives for the role of PCAT in the pathophysiology of atherosclerosis and should be further investigated.

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Section: Discussionmentioning

confidence: 99%

Differences in MicroRNA Expression in Pericoronary Adipose Tissue in Coronary Artery Disease Compared to Severe Valve Dysfunction

et al. 2022

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“…There is increasing evidence that epicardial fat thickness (EFT) and epicardial fat volume (EFV), as measured by echocardiography, computed tomography (CT), or magnetic resonance image (MRI), are independent risk factors for the presence and severity of atrial fibrillation [ 3 , 21 , 22 ]. Furthermore, very recent clinical data found that EFT and EFV were significantly associated with AF recurrence after pulmonary vein isolation with at least 1-year follow-up [ 23 ], which was consistent with the findings of a systematic review and meta-analysis [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Patients with Angiographically-Confirmed Coronary Artery Disease to Investigate the Association Between Epicardial Fat Thickness and Atrial Fibrillation

Ren

Wang

et al. 2022

Med Sci Monit

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Background Epicardial fat thickness (EFT) is increasingly recognized as an independent risk factor of the presence, severity, and recurrence of atrial fibrillation (AF). We investigated the associations between EFT and AF prevalence and identified its correlation with other risk factors. Material/Methods A total of 199 participants who underwent coronary angiography and had confirmed coronary artery disease (CAD) were enrolled in this study. The EFT was measured by echocardiography and the association of EFT with other AF risk factors was evaluated by multivariate logistic regression analysis. Results The EFT was significantly higher in patients with comorbidity of AF and CAD than those with CAD alone (6.86±1.96 mm vs 5.91±1.71 mm, P <0.001). Logistic regression analysis indicated that EFT was a predictive factor of the occurrence of AF in CAD, after adjusting for body mass index (BMI), systolic blood pressure (SBP), left circumflex artery (LCX) stenosis, LA diameter, B-type natriuretic peptide (BNP), creatinine (Cr), and blood urea nitrogen (BUN). LA diameter, SBP, and LCX stenosis are also independent risk factors for CAD complicated by AF. Correlation analysis revealed significant positive linear correlations between EFT and BMI ( P <0.01), EFT, and LA diameter ( P <0.05), as well as positive correlations between LA diameter and BNP, Cr, or BUN. Conclusions Epicardial fat thickness is a strong predictor for AF prevalence in patients with CAD, independent of other AF risk factors such as LA diameter, BMI, and SBP, while LA diameter, SBP, and LCX stenosis are also independent AF risk factors for CAD.

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“…Over the last decade, the associations between eat volume, eat density (Ct attenuation coefficient), and aF or its recurrence have been extensively studied. table 2 summarises the studies searching for associations between eat volume, eat density, and aF, published between January 2020 and March 2022 [107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][124][125]. Most of these latter studies found that a higher eat volume, both total-eat volume and La-eat (eat surrounding the left atrium) volume, is associated with a higher prevalence of aF, a higher incidence of postoperative atrial fibrillation (POaF) after coronary artery bypass graft (CaBG), and a higher aF recurrence rate after aF ablation.…”

Section: Eat and Afmentioning

confidence: 99%

Computed tomography measured epicardial adipose tissue and psoas muscle attenuation: new biomarkers to predict major adverse cardiac events (MACE) and mortality in patients with heart disease and critically ill patients. Part I: Epicardial adipose tissue

Walpot,

Van Herck,

Van de Heyning

et al. 2023

ait

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Over the last two decades, the potential role of epicardial adipocyte tissue (EAT) as a marker for major adverse cardiovascular events has been extensively studied.Unlike other visceral adipocyte tissues (VAT), EAT is not separated from the adjacent myocardium by a fascial layer and shares the same microcirculation with the myocardium. Adipocytokines, secreted by EAT, interact directly with the myocardium through paracrine and vasocrine pathways. The role of the Randle cycle, linking VAT accumulation to insulin resistance, and the relevance of blood flow and mitochondrial function of VAT, are briefly discussed.The three available imaging modalities for the assessment of EAT are discussed. The advantages of echocardiography, cardiac CT, and cardiac magnetic resonance (CMR) are compared.The last section summarises the current stage of knowledge on EAT as a clinical marker for major adverse cardiovascular events (MACE). The association between EAT volume and coronary artery disease (CAD) has robustly been validated. There is growing evidence that EAT volume is associated with computed tomography coronary angiography (CTCA) assessed high-risk plaque features. The EAT CT attenuation coefficient predicts coronary events. Many studies have established EAT volume as a predictor of atrial fibrillation after cardiac surgery. Moreover, EAT thickness has been independently associated with severe aortic stenosis and mitral annular calcification. Studies have demonstrated that EAT volume is associated with heart failure. Finally, we discuss the potential role of EAT in critically ill patients admitted to the intensive care unit.In conclusion, EAT seems to be a promising new biomarker to predict MACE.

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A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography

Cited by 5 publications

References 33 publications

Differences in MicroRNA Expression in Pericoronary Adipose Tissue in Coronary Artery Disease Compared to Severe Valve Dysfunction

Differences in MicroRNA Expression in Pericoronary Adipose Tissue in Coronary Artery Disease Compared to Severe Valve Dysfunction

Evaluation of Patients with Angiographically-Confirmed Coronary Artery Disease to Investigate the Association Between Epicardial Fat Thickness and Atrial Fibrillation

Computed tomography measured epicardial adipose tissue and psoas muscle attenuation: new biomarkers to predict major adverse cardiac events (MACE) and mortality in patients with heart disease and critically ill patients. Part I: Epicardial adipose tissue

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