A Structural and In Silico Investigation of Potential CDC7 Kinase Enzyme Inhibitors
Mohanbabu Mookkan,
Saravanan Kandasamy,
Abdel-Basit Al-Odayni
et al.
Abstract:A crucial role in the regulation of DNA replication is
played by
the highly conserved CDC kinase. The CDC7 kinase could serve as a
target for therapeutic intervention in cancer. The primary heterocyclic
substance is pyrazole, and its derivatives offer great potential as
treatments for cancer cell lines. Here, we synthesized the two pyrazole
derivatives: 4-(2-(4-chlorophenyl)hydrazinyl)-5-methyl-2-tosyl-1H-pyrazol-3(2H)-one
(PYRA-1) and 4-(2-(2,4-difluorophenyl)hydrazinyl)-5-methyl-2-tosyl-1H-pyrazol-3(2H)-one
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