We introduce nominal string diagrams as, string diagrams internal in the category of nominal sets. This requires us to take nominal sets as a monoidal category, not with the cartesian product, but with the separated product. To this end, we develop the beginnings of a theory of monoidal categories internal in a symmetric monoidal category. As an instance, we obtain a notion of a nominal PROP as a PROP internal in nominal sets. A 2-dimensional calculus of simultaneous substitutions is an application.