“…The associations between symptoms and functional status, general health perceptions, and overall QOL were supported by 13, three, and seven studies, respectively. For instance, more severe symptoms were significantly associated with poorer physical functioning in patients with HIV/AIDS (Alsayed et al, 2017), Parkinson's disease (Chekani et al, 2016), ESRD (Jung & Kim, 2020), heart failure (Lawson et al, 2018), COPD (Peepratoom et al, 2020), and fibromyalgia (Rutledge et al, 2007); in healthy women (Savoy & Penckofer, 2015); and in the elderly (McKay et al, 2020;Spoelstra et al, 2010a;2010b;. Also, more severe symptoms were significantly associated with poorer general health perceptions in patients having HIV/AIDS (Alsayed et al, 2017) and heart failure (Lawson et al, 2018) as well as with lower overall QOL in patients having ESRD (Jung & Kim, 2020), heart disease (Kang et al, 2018;Wang et al, 2016), breast cancer (Oh & Cho, 2020), and COPD (Peepratoom et al, 2020) and in healthy women (Savoy & Penckofer, 2015).…”