A structural platform for B cell receptor signaling

Xie, Wei; Wucherpfennig, Kai W.; Patel, Dinshaw J.

doi:10.1038/s41422-022-00724-9

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Intracellular domains of CD79a and CD79b have an immunoreceptor tyrosine-based activation motif (ITAM) made up of 26 amino acid residues and containing two critical immunoglobulin interacts with the top of the CD79a/CD79b complex. It further suggests isotype specific differences in BCR signaling [74,75].…”

Section: Extracellular Transmembrane and Intracellular Domains Of Cd7...mentioning

confidence: 88%

“…Interactions between Ig and CD79a/CD79b complex result in the formation of four-helix transmembrane bundle whose conserved nature assures correct assembly of any BCR isotype [ 60 , 74 ]. These tight interactions within the cell membrane are crucial for the assembly, stability and functionality of BCR, suggesting co-folding of BCR components during BCR complex formation [ 63 ].…”

Section: Extracellular Transmembrane and Intracellular Domains Of Cd7...mentioning

confidence: 99%

“…The IgM immunoglobulin binds to the CD79a/CD79b heterodimer extracellular domain from the side, whereas the IgG immunoglobulin interacts with the top of the CD79a/CD79b complex. It further suggests isotype specific differences in BCR signaling [ 74 , 75 ].…”

Section: Extracellular Transmembrane and Intracellular Domains Of Cd7...mentioning

confidence: 99%

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B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells

Tkachenko,

Kupcova,

Havranek

2023

IJMS

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B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential components of BCR that are indispensable for its functionality, signal initiation, and signal transduction. CD79a/CD79b-mediated BCR signaling is required for the survival of normal as well as malignant B cells via a wide signaling network. Recent studies identified the great complexity of this signaling network and revealed the emerging role of CD79a/CD79b in signal integration. In this review, we have focused on functional features of CD79a/CD79b, summarized signaling consequences of CD79a/CD79b post-translational modifications, and highlighted specifics of CD79a/CD79b interactions within BCR and related signaling cascades. We have reviewed the complex role of CD79a/CD79b in multiple aspects of normal B cell biology and how is the normal BCR signaling affected by lymphoid neoplasms associated CD79A/CD79B mutations. We have also summarized important unresolved questions and highlighted issues that remain to be explored for better understanding of CD79a/CD79b-mediated signal transduction and the eventual identification of additional therapeutically targetable BCR signaling vulnerabilities.

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Section: Extracellular Transmembrane and Intracellular Domains Of Cd7...mentioning

confidence: 88%

Section: Extracellular Transmembrane and Intracellular Domains Of Cd7...mentioning

confidence: 99%

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B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells

Tkachenko,

Kupcova,

Havranek

2023

IJMS

View full text Add to dashboard Cite

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Biomaterials-mediated ligation of immune cell surface receptors for immunoengineering

Cui,

Zhang,

Shi

2024

Immuno-Oncology and Technology

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A structural platform for B cell receptor signaling

Cited by 2 publications

References 13 publications

B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells

B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells

Biomaterials-mediated ligation of immune cell surface receptors for immunoengineering

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