A structured model of dual-limitation kinetics

Bae, Wookeun; Rittmann, Bruce E.

doi:10.1002/(sici)1097-0290(19960320)49:6<683::aid-bit10>3.0.co;2-7

Cited by 83 publications

(53 citation statements)

References 13 publications

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“…Microbial specific growth rate approaches: multiple substrate Monod kinetics [17,18,19], growth inhibition by product formation according to the Levenspiel [20], growth inhibition by product formation described by the Jerusalimsky [21], Monod kinetics and acetate growth inhibition described by Andrews kinetics [22]. Product formation kinetics: product formation based on the Luedeking-Piret [23], product formation according to the Michaelis-Menten equation for non-competitive inhibition with product [24] and product formation and product inhibition described by the modified Luedeking The fed-batch fermentation feed medium consisted of 700 g L )1 glucose monohydrate and 109 g L )1 potassium acetate.…”

Section: Methodsmentioning

confidence: 99%

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Modeling of the pyruvate production with Escherichia coli in a fed-batch bioreactor

Zelić

Vasić-Rački

Wandrey

et al. 2004

Bioprocess Biosyst Eng

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A family of 10 competing, unstructured models has been developed to model cell growth, substrate consumption, and product formation of the pyruvate producing strain Escherichia coli YYC202 ldhA::Kan strain used in fed-batch processes. The strain is completely blocked in its ability to convert pyruvate into acetyl-CoA or acetate (using glucose as the carbon source) resulting in an acetate auxotrophy during growth in glucose minimal medium. Parameter estimation was carried out using data from fed-batch fermentation performed at constant glucose feed rates of q(VG)=10 mL h(-1). Acetate was fed according to the previously developed feeding strategy. While the model identification was realized by least-square fit, the model discrimination was based on the model selection criterion (MSC). The validation of model parameters was performed applying data from two different fed-batch experiments with glucose feed rate q(VG)=20 and 30 mL h(-1), respectively. Consequently, the most suitable model was identified that reflected the pyruvate and biomass curves adequately by considering a pyruvate inhibited growth (Jerusalimsky approach) and pyruvate inhibited product formation (described by modified Luedeking-Piret/Levenspiel term).

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Section: Methodsmentioning

confidence: 99%

“…The ''multiple substrates Monod kinetics'' was used in models 1 and 2 [17,18,19]. However, it is known that this kinetic term has an inherent disadvantage if many essential substrates are considered.…”

Section: Microbial Growthmentioning

confidence: 99%

Modeling of the pyruvate production with Escherichia coli in a fed-batch bioreactor

Zelić

Vasić-Rački

Wandrey

et al. 2004

Bioprocess Biosyst Eng

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show abstract

“…In addition, the model is based on a dual-substrate model for oxygen as a cosubstrate with the multiplicative form suggested by Bae and Rittmann (1996). The biodegradation rate of compound j dissolved in liquid (R d b,j ; mg j/h) is expressed as:…”

Section: Biodegradation and Biomass Growthmentioning

confidence: 99%

Evaluation of the interaction between biodegradation and sorption of phenanthrene in soil-slurry systems

Woo

Park

Rittmann

2001

Biotechnol. Bioeng.

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“…As indicated by Grady et al, (1999), relatively little is known about how microorganisms respond to simultaneous limitation of two or more complementary nutrients. However, Bae and Rittmann (1996) have shown that the interactive model is more appropriate when the two limiting constituents are the electron donor and the electron acceptor, as would be the case here. An interactive model is based upon the assumption that two complementary nutrients can both influence the specific growth rate at the same time (for example, if two complementary nutrients are present at concentrations equal to their half saturation coefficients, then each together will reduce the specific growth rate to half the maximum, resulting in an overall reduction to one-fourth the maximum).…”

Section: Discussionmentioning

confidence: 70%

Development of a Conceptual Model to Explain Apparent Free Ammonia Inhibition in Wastewater Systems (WEFTEC 2006)

Simm¹,

Mavinic²,

Ramey³

2006

proc water environ fed

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The common consensus among researchers and practitioners alike is that high free ammonia concentrations cause nitrite oxidizer inhibition in wastewater treatment systems. The work of Anthonisen et al. (1976), who produced an operational chart providing guidance on the free ammonia concentrations most likely to produce nitrite oxidizer inhibition, is considered by many to be the definitive work that established the inhibitory nature of free ammonia in wastewater treatment systems. Over the past three decades several investigators have reported discrepancies in the range of inhibitory free ammonia concentrations. Anthonisen et al. (1976) reported inhibition of nitrite-oxidizers at free ammonia concentrations of 0.1 to 1 mg/L, Turk and Mavinic (1986) reported no significant nitrite-oxidizer inhibition for free ammonia concentrations below 10 mg NH 3 -N/L, whereas Mauret et al. (1996) concluded that free ammonia inhibits Nitrobacter, in the range of 6.6 to 8.9 mg NH 3 -N/L. On the other hand, Gieseke et al. (2003) state that it is not known whether bacteria of the genus Nitrospira, now believed to be the most prevalent nitrite oxidizer in wastewater systems, are inhibited by free ammonia.Some investigators have called into question the true cause of observed nitrite oxidizer inhibition. For example, Cecen and Ipek (1998) suggested that the dissolved oxygen to free ammonia ratio and not the free ammonia concentration itself is important, when attempting to induce nitrite accumulation. The work of others (Stuven et al. 1992;Yang and Alleman 1992;and Hyungseok Yoo et al. 1999) has suggested that hydroxylamine -an intermediate in the ammonia oxidation process -may be the true cause of nitrite oxidizer inhibition and therefore of nitrite accumulation. Many authors agree; however, that selective inhibition of nitrite oxidation via apparent free ammonia inhibition would allow direct oxidation of ammonia to nitrite and denitrification to dinitrogen gas with the inherent benefits of reduced aeration and carbon requirements. The starting point to designing such a process is the development of a clearer understanding of the mechanism(s) associated with nitrite oxidizer inhibition and nitrite accumulation. This paper describes the results of exploratory work conducted to both confirm the results of mixed culture batch tests suggesting free ammonia may not be inhibitory to nitrite oxidizers as commonly reported and elucidate the likely mechanism(s) responsible for observed phenomenon. Free ammonia inhibition trials were undertaken using pure cultures of Nitrospira moscoviensis, since Nitrospira spp. were the predominant nitrite-oxidizers in the systems studied for this research program. The results of these experiments support the conclusion that free ammonia is probably not inhibitory to nitrite-oxidizing organisms in wastewater systems. 6548 WEFTEC®.06Copyright 2006 Water Environment Foundation. All Rights Reserved © Several long-term reactor perturbation studies were conducted with mixed microbial cultures to identi...

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A structured model of dual-limitation kinetics

Cited by 83 publications

References 13 publications

Modeling of the pyruvate production with Escherichia coli in a fed-batch bioreactor

Modeling of the pyruvate production with Escherichia coli in a fed-batch bioreactor

Evaluation of the interaction between biodegradation and sorption of phenanthrene in soil-slurry systems

Development of a Conceptual Model to Explain Apparent Free Ammonia Inhibition in Wastewater Systems (WEFTEC 2006)

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