A study for maternal thyroid hormone deficiency during the first half of pregnancy in China

Shan, Zhongyan; Chen, Y. Y.; Wang, Teng; Yu, Xiao‐Juan; Li, C. Y.; Zhou, Weiwei; Gao, Bo; Zhou, Jiaren; Ding, Bin; Ma, Ying; Wu, Ying; Liu, Q.; Hu, Xu; Liu, W.; Li, J.; Wang, W. W.; Li, Y. B.; Fan, Chenling; Wang, H.; Guo, Rui; Zhang, H. M.

doi:10.1111/j.1365-2362.2008.02055.x

Cited by 68 publications

(52 citation statements)

References 20 publications

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“…In this study, we evaluated the prevalence of thyroid dysfunction by screening 2899 pregnant women using the first trimester-specific reference intervals from our previous work (10). The results showed that high-risk women, classified based on Endocrine Society Clinical Practice Guidelines (9), had more than a 1.5-fold increased risk of hypothyroidism (subclinical or overt) and a 1.7-fold increased risk of hyperthyroidism (subclinical or overt) during early pregnancy than did women in the non-high-risk group.…”

Section: Discussionmentioning

confidence: 99%

“…The first trimester-specific reference intervals used to diagnose thyroid dysfunctions were based on those determined previously (10). The first trimester-specific reference ranges for TSH, FT 4 , and FT 3 were 0.13-3.93 mIU/l, 12.00-23.34 pM, and 3.46-7.70 pM respectively.…”

Section: And Diagnostic Criteriamentioning

confidence: 99%

“…The first trimester-specific reference ranges for TSH, FT 4 , and FT 3 were 0.13-3.93 mIU/l, 12.00-23.34 pM, and 3.46-7.70 pM respectively. Overt hypothyroidism, subclinical hypothyroidism, and hypothyroxinemia were defined by the first trimester-specific reference intervals for TSH, FT 3 , and FT 4 as described previously (10). Overt hyperthyroidism and subclinical hyperthyroidism were identified as decreased TSH levels with increased FT 3 or FT 4 and with a normal range of FT 3 or FT 4 respectively.…”

Section: And Diagnostic Criteriamentioning

confidence: 99%

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The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy

Wang¹,

Wang²,

Shan³

et al. 2011

European Journal of Endocrinology

105

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Context: Maternal thyroid disorders during early pregnancy can influence pregnancy outcome and fetal development. The recent Endocrine Society Clinical Practice Guideline recommends a casefinding approach in which pregnant women who are at high risk for developing thyroid disease are tested. Objective: The purpose of this study was to use the first trimester-specific reference intervals of thyroidrelated hormones to explore the prevalence of thyroid dysfunction during early pregnancy and to analyze effectiveness of different screening strategies. Design: A multicenter cohort study. Method: A total of 2899 pregnant women were enrolled in this study during their first trimester of gestation. Levels of TSH, free thyroxine, free triiodothyronine, and thyroid peroxidase antibodies (TPOAb) were measured and thyroid disorders of pregnant women were diagnosed based on the first trimester-specific reference intervals. Results: The prevalence of hypothyroidism was significantly higher in the high-risk group than in the non-high-risk group (10.9 vs 7.0%, c 2 Z7.1, PZ0.008). The prevalence of hyperthyroidism was not significantly different between the high-risk group and the non-high-risk group (2.7 vs 1.6%, c 2 Z2.27, PZ0.13). Elevated levels of TPOAb and a personal history of thyroid disease increased the risk of thyroid dysfunction. Conclusions: A case-finding strategy for screening thyroid function in the high-risk group would miss about 81.6% pregnant women with hypothyroidism and 80.4% pregnant women with hyperthyroidism.

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Section: Discussionmentioning

confidence: 99%

Section: And Diagnostic Criteriamentioning

confidence: 99%

Section: And Diagnostic Criteriamentioning

confidence: 99%

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The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy

Wang¹,

Wang²,

Shan³

et al. 2011

European Journal of Endocrinology

105

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“…Many studies have shown lower prevalence estimates of hypothyroidism among pregnant women [14][15][16][17][18]. One of the reasons for this discrepancy is thought to be the gestational age at which screening is performed.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors for hypothyroidism in Jordanian women: comparison between different reference ranges

Alkafajei

Amarin²,

Alazaizeh³

et al. 2012

East Mediterr Health J

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The aim of this cross-sectional study in Jordan was to estimate the prevalence of hypothyroidism among women during early pregnancy and to assess the association of risk factors with hypothyroidism. According to internationally adopted thyroid stimulating hormone (TSH) and thyroxine (T 4 ) pregnancy reference ranges (TSH ≥ 2.6 mIU/L and T 4 10.6-20.4 pmol/L), 67 of 322 (20.8%) women were diagnosed with sub-clinical hypothyroidism. When the general laboratory criteria were applied (TSH ≥ 4.6 mIU/L and T 4 < 10.6 pmol/L) the prevalence dropped to 4.3%. No cases of overt hypothyroidism were diagnosed using either diagnostic criterion. Younger age and being in gestational weeks 1-8 were significant risk factors for hypothyroidism. It is suggested that the reference criteria need revision, and that pathology laboratories should adopt appropriate pregnancyspecific reference intervals.

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“…The incidence of this special hormonal state during pregnancy varies among wide intervals, depending on the iodine status of the geographical area, the trimester-specific hormonal assays and the used normal ranges, thus according to these influencing factors published data showed an incidence ranging between 1.3-26.5% (Casey et al, 2007;Vaidya et al, 2007;Clear-Goldman et al, 2008;Berbel et al, 2009;Moleti et al, 2009;Shan et al 2009;Hendrichs et al, 2010). The prevalence is the lowest in the first gestational trimester (1.2-3.2%) but than it starts to increase gradually during the II.…”

Section: Iodine Dose (μG/day) Organization and Date Median Urinary Iomentioning

confidence: 99%

Screening of High-Risk Pregnant Women for Thyroid Dysfunctions in a Moderately Mild Iodine-Deficient Area

Kun¹,

Szántó²,

Kun³

et al. 2012

State of the Art of Therapeutic Endocrinology

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A study for maternal thyroid hormone deficiency during the first half of pregnancy in China

Cited by 68 publications

References 20 publications

The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy

The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy

Prevalence and risk factors for hypothyroidism in Jordanian women: comparison between different reference ranges

Screening of High-Risk Pregnant Women for Thyroid Dysfunctions in a Moderately Mild Iodine-Deficient Area

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