A study of 28 flat bone osteosarcomas: prognostic factors and early and long-term outcome

Salas, Sébastien; Huynh, Thanh; Giorgi, Roch; Deville, Jean Laurent; Bollini, G.; Curvale, G.; Blesius, Aurore; Gentet, Jean Claude; Bui, Binh; Bouvier, C; Duffaud, Florence

doi:10.1111/j.1365-2354.2009.01152.x

Cited by 3 publications

(1 citation statement)

References 30 publications

(86 reference statements)

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“…For example, osteosarcomas typically are long-bone tumors and rarely affect the flat bones of the axial or appendicular skeleton [3,13,24]. Chondrosarcoma often occurs in flat bones, such as the pelvis, ribs, and scapula [21].…”

Section: Discussionmentioning

confidence: 99%

Primary clavicle tumors and tumorous lesions: a review of 206 cases in East Asia

Kawaguchi

Shi

et al. 2012

Arch Orthop Trauma Surg

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Clavicle tumors and tumorous lesions in East Asia had an inclined occurrence in respect to age and gender. The most common tumors were eosinophilic granuloma and tumors derived from the bone marrow hematopoietic system. Age of onset was found to be a risk factor for malignancy. These characteristics may be related to the special tissue structures and mode of development in the clavicle as well as to the genetic traits of the typical Mongoloids in East Asia.

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Section: Discussionmentioning

confidence: 99%

Primary clavicle tumors and tumorous lesions: a review of 206 cases in East Asia

Kawaguchi

Shi

et al. 2012

Arch Orthop Trauma Surg

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Clinical and imaging features of 112 patients with irregular and flat bone osteosarcoma

Luo¹,

Jing²,

Qin³

et al. 2022

Quant Imaging Med Surg

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Background: This study evaluated the clinical characteristics and imaging findings of 112 patients with irregular and flat bone osteosarcoma (IFBO). Methods:The age, gender, location, tumor size, density and signal intensity, osteoid matrix, periosteal reaction, and histological subtypes were analyzed for 112 patients with IFBO.Results: A total of 112 patients with IFBO, including 64 males and 48 females, with a mean age of 34.8 years were enrolled in this study. Over half of the tumors (54.5%) were detected in the craniofacial region and the skull (24 in the maxilla bone, 17 in the mandible bone, 11 in the sphenoid bone, 7 in the temporal bone, 1 in the frontal bone, and 1 in the occipital bone). Other tumor locations included the pelvic region (20.5%; 20 in the ilium and 3 in the pubis), the chest (18.8%; 11 in the scapula, 7 in the ribs, and 3 in the clavicle), and the vertebrae (6.3%; 3 in the thoracic spine, 2 in the lumbar spine, 1 in the sacrum, and 1 in the cervical spine). Transarticular extension occurred in 11 of the 23 pelvic cases (47.8%), primarily involving the sacroiliac joint (90.9%; 10 of 11). Six cases (6/7; 85.7%) of vertebral osteosarcoma arose from the transverse process and the pedicle, and 1 (1/7; 14.3%) arose from the sacral tuberosity and the ala, with partial vertebral body involvement. Additionally, 27 patients (24.1%) presented with secondary osteosarcoma related to prior radiotherapy, and 2 (1.8%) were associated with osteoblastoma and fibrous dysplasia.Histological examination revealed high-grade tumors in 88 (78.6%) cases. The tumors presented as softtissue masses with a diameter of 7.5±3.2 cm. A total of 91 patients underwent X-ray examination and/or computed tomography (CT) examinations. The osteoid matrix was detected in 84 patients (84/91;92.3%).A periosteal reaction was detected in 56 cases (56/91; 61.5%), including a lamellar periosteal reaction in 10 patients (11.0%) and a spiculated periosteal reaction in 46 cases (50.5%). All 74 cases who underwent magnetic resonance imaging (MRI) examinations presented with heterogeneous masses in the surrounding soft tissue. Enhancement was homogenous in 12 cases (18.5%) and heterogeneous in 53 cases (81.5%).Peripheral rim enhancement was observed in 10 cases (13.5%).Conclusions: IFBO should be considered when diagnosing patients over 30 years of age who exhibit osteoid matrix in bone lesions. Maxillofacial osteosarcoma is commonly associated with a history of radiation

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Magnetic Resonance Imaging Texture Analysis Based on Intraosseous and Extraosseous Lesions to Predict Prognosis in Patients with Osteosarcoma

Mori,

Ren,

Mori

et al. 2024

Diagnostics

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Objectives: To construct an optimal magnetic resonance imaging (MRI) texture model to evaluate histological patterns and predict prognosis in patients with osteosarcoma (OS). Methods: Thirty-four patients underwent pretreatment MRI and were diagnosed as having OS by surgical resection or biopsy between September 2008 and June 2018. Histological patterns and 3-year survival were recorded. Manual segmentation was performed in intraosseous, extraosseous, and entire lesions on T1-weighted, T2-weighted, and contrast-enhanced T1-weighted images to extract texture features and perform principal component analysis. A support vector machine algorithm with 3-fold cross-validation was used to construct and validate the models. The area under the receiver operating characteristic curve (AUC) was calculated to evaluate diagnostic performance in evaluating histological patterns and 3-year survival. Results: Eight patients were chondroblastic and the remaining twenty-six patients were non-chondroblastic patterns. Twenty-seven patients were 3-year survivors, and the remaining seven patients were non-survivors. In discriminating chondroblastic from non-chondroblastic patterns, the model from extraosseous lesions on the T2-weighted images showed the highest diagnostic performance (AUCs of 0.94 and 0.89 in the training and validation sets). The model from intraosseous lesions on the T1-weighted images showed the highest diagnostic performance in discriminating 3-year non-survivors from survivors (AUCs of 0.99 and 0.88 in the training and validation sets) with a sensitivity, specificity, positive predictive value, and negative predictive value of 85.7%, 92.6%, 75.0%, and 96.2%, respectively. Conclusions: The texture models of extraosseous lesions on T2-weighted images can discriminate the chondroblastic pattern from non-chondroblastic patterns, while the texture models of intraosseous lesions on T1-weighted images can discriminate 3-year non-survivors from survivors.

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A study of 28 flat bone osteosarcomas: prognostic factors and early and long-term outcome

Cited by 3 publications

References 30 publications

Primary clavicle tumors and tumorous lesions: a review of 206 cases in East Asia

Primary clavicle tumors and tumorous lesions: a review of 206 cases in East Asia

Clinical and imaging features of 112 patients with irregular and flat bone osteosarcoma

Magnetic Resonance Imaging Texture Analysis Based on Intraosseous and Extraosseous Lesions to Predict Prognosis in Patients with Osteosarcoma

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