A Study of an Effect on Moisture from 3D Printer Filament Drying Processes

Limpadapun, Khompee; Sukmanee, Jenjira

doi:10.4028/www.scientific.net/kem.902.101

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…In addition, a study by Löbmann and colleagues [33] found that both convection and microwave-induced radiation play a crucial role in promoting in situ drug amorphization, which can influence their bioavailability and clinical effectiveness. Some of these studies have investigated different drying methods, with the expectation that the heating mechanism underlying microwave drying might be more beneficial to the performance and quality of the products [33][34][35][36]. However, the work published to date has focused on the application of the drying step only to intermediate products obtained by HME.…”

Section: Introductionmentioning

confidence: 99%

Exploring Environmental Settings to Improve the Printability of Paroxetine-Loaded Filaments by Fused Deposition Modelling

Figueiredo,

Fernandes,

Carvalho

et al. 2023

Pharmaceutics

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The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial to enable three-dimensional printing (3DP). Hence, the objective of this work was to investigate the correlation between the environmental settings and the properties of paroxetine (PRX)-loaded filaments, previously produced by HME, which affect printability by FDM. The influence of different drying methods of the physical mixtures (PMs) and HME-filaments (FILs) on the quality and printability of these products was also assessed. The printability of FILs was evaluated in terms of the water content, and the mechanical and thermal properties of the products. Stability studies and physicochemical, thermal, and in vitro dissolution tests were carried out on the 3D-printed tablets. Stability studies demonstrated the high ductility of the PRX loaded FILs, especially under high humidity conditions. Under low humidity storage conditions (11% RH), the FILs became stiffer and were successfully used to feed the FDM printer. Water removal was slow when carried out passively in a controlled atmosphere (desiccator) or accelerated by using active drying methods (heat or microwave). Pre-drying of the PRX/excipients and/or PMs did not show any positive effect on the printability of the FIL. On the contrary, dry heat and, preferably, microwave mediated drying processes were shown to reduce the holding time required for successful FDM printing, enabling on-demand production at the point of care.

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