A study of anal function after sphincter-preserving operation for lower rectal cancer.

Kuromizu, J.

doi:10.3862/jcoloproctology.42.10

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Anal continence improved in all cases after taking diazepam, with improvements in grade or frequency of incontinence, a reduction in need to wear a pad and fewer lifestyle alterations. Soiling or fecal incontinence after low anterior resection usually subsides in 6-12 months without any treatment in most cases [1][2][3][4][5]. The prompt improvement of incontinence as observed in this preliminary report suggests that diazepam has some effect on incontinence.…”

Section: Discussionmentioning

confidence: 50%

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Effect of oral diazepam on anal continence after low anterior resection: a preliminary study

et al. 2002

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The aim of the present study was to investigate the effect of oral diazepam on anal incontinence after low anterior resection for rectal cancer. Five patients with persistent incontinence after low anterior resection for rectal cancer (median level of anastomosis was 4.0 cm from the anal verge) were treated with oral diazepam (2 mg/day) 9-90 months after surgery. Grade and frequency of anal incontinence, the need for a protective pad and changes of lifestyle were recorded to the Cleveland Clinic's continence grading scale; anorectal manometry was performed before and after 3 months of treatment. All patients improved on treatment although occasional minor soiling persisted in two patients. Continence score improved from 14 (median, range 9-16) to 0 (range 0-12) after taking diazepam. Improvement occurred within a week after administration of diazepam. Although the patients improved symptomatically, anorectal manometry failed to demonstrate any significant changes. In conclusion, oral administration of diazepam may be worthwhile in the attempt to improve anal continence after low anterior resection.

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Section: Discussionmentioning

confidence: 50%

“…Although function improves with time in most patients [1][2][3][4][5], persisting symptoms may interfere with quality of life in others [3,4]. Few effective measures to manage these problems have been reported [6,7].…”

Section: Introductionmentioning

confidence: 98%