A study of association between genetic markers in candidate genes and reproductive traits in one generation of a commercial broiler breeder hen population

Dunn, Ian; Miao, Yi-Wei; Morris, Adam P.; Romanov, Michael N; Wilson, Peter W.F.; Waddington, David

doi:10.1038/sj.hdy.6800396

Cited by 62 publications

(58 citation statements)

References 34 publications

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“…However, no significant differences were observed among genotypes at the phenotypic level (Table 5). Dunn et al (2004) found a significant association between GnRHR gene and the number of double-yolk eggs in a commercial broiler breeder hen population. Dominance effect of this gene on egg number in Wenchang chicken was reported by Wu et al (2007).…”

Section: Discussionmentioning

confidence: 99%

“…Table 1. Primers used for amplification of the genes (Dunn et al, 2004). SNP = single nucleotide polymorphism.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Some genetic markers in the NPY gene may be associated with age at first egg. Also, NPY may affect egg production rate through its role in the control of ovulation (Dunn et al, 2004). The close association of NPY and GnRH perikarya and fibers in the chick brain suggests a functional interaction between the two peptides in regulating gonadal function (Kuenzel, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…It acts by binding to specific GnRH receptors on the membrane of pituitary gonadotropes, where it stimulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (Hattori et al, 1986;Pawson and McNeilly, 2005). An additive genetic effect of the GnRHR gene on the number of double-yolk eggs has been found (Dunn et al, 2004). GnRH and its receptor start the cascade that produces the appropriate growth, maturation and maintenance of the gonads (Dunn et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…An additive genetic effect of the GnRHR gene on the number of double-yolk eggs has been found (Dunn et al, 2004). GnRH and its receptor start the cascade that produces the appropriate growth, maturation and maintenance of the gonads (Dunn et al, 2004). …”

Section: Introductionmentioning

confidence: 99%

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Association of neuropeptide Y and gonadotrophin-releasing hormone receptor gene SNPs with breeding value for growth and egg production traits in Mazandaran native chickens

Fatemi¹,

Mehrabani-Yeganeh²,

Nejati‐Javaremi³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Neuropeptide Y (NPY) and gonadotrophin-releasing hormone receptor (GnRHR) are two candidate genes with a wide variety of physiological functions in growth and especially in reproduction processes. We examined the association of one SNP from each of these genes with growth-and egg production-related traits in Mazandaran native chickens. Two hundred and six individuals were genotyped by PCR-RFLP. Marker-trait association analyses were performed using both breeding value and phenotypic information. The data came from 18 successive generations of selection at a Mazandaran native chicken breeding station in Iran. Data were analyzed with a univariate animal model in an ASREML procedure to estimate breeding values of the birds for these traits. Two alleles were found for both genes, A and a alleles for GnRHR, with frequencies of 0.614 and 0.386, B and b alleles for NPY, with frequencies of 0.780 and 0.221, respectively.

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Section: Discussionmentioning

confidence: 99%

“…Table 1. Primers used for amplification of the genes (Dunn et al, 2004). SNP = single nucleotide polymorphism.…”

Section: Statistical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association of neuropeptide Y and gonadotrophin-releasing hormone receptor gene SNPs with breeding value for growth and egg production traits in Mazandaran native chickens

Fatemi¹,

Mehrabani-Yeganeh²,

Nejati‐Javaremi³

et al. 2012

Genet. Mol. Res.

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Identification of differentially expressed known and novel miRNAs in broodiness of goose

Chen

Zhang

et al. 2014

Mol Biol Rep

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MicroRNAs (miRNAs) are endogenous small noncoding RNAs plays a critical role in posttranscriptional regulation of gene expression. Broodiness is observed in most avian species and influences egg production. Several genes are known to play an important role in regulating the progress of reproduction. The goose is one of the most important waterfowls. However, the involvement of miRNAs in the broodiness behavior of Anser cygnoides (Swan Goose) is unknown. High-throughput sequencing and bioinformatics analysis were used to identify the miRNAs involved in egg-laying and brooding behavior of geese in our study. The results showed 38 up-regulated and 14 down-regulated known miRNAs/miRNA*s with reads>1,000 in at least one group and a fold change of >2.0, compared with those of the egg-laying group (P<0.001). We also identified 114 and 94 novel miRNAs in the broody and egg-laying groups, respectively. Of these, 4 novel miRNAs were differentially expressed between the two groups. The study showed the expression of small RNAs in goose reproduction and identified known and novel miRNAs regulated in broodiness. The results reveal that these differentially expressed miRNAs may be involved in broodiness of A. cygnoides.

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Differential expression profiling of hypothalamus genes in laying period and ceased period Huoyan geese

Cao

et al. 2014

Mol Biol Rep

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The hypothalamus plays a central role in controlling poultry reproductive activity. To increase our understanding of genes involved in egg laying of Huoyan geese, gene profiles in the hypothalamus of laying period and ceased period Huoyan geese were investigated using suppression subtractive hybridization (SSH) method. A total of 95 differentially expressed sequence tags (ESTs), including 46 up-regulated and 49 down-regulated sequences showed homology to known genes of the non-redundant NCBI databases. Bioinformatic analysis demonstrated that these genes were mainly involved in anatomical structure development, signal transduction, cellular nitrogen compound metabolic process, biosynthetic process, cellular protein modification process, cell differentiation, transport, cell adhesion, and reproduction. Ten ESTs were selected for further analyses by quantitative real-time RT-PCR (qRT-PCR). Whose most part of results were consistent with the SSH results. Of note, AdipoR2, Nrg1, and NCAM1, which related with secretion of GnRH and other hormones, were identified to be differentially expressed between laying period and ceased period. These findings provided a new source for mining genes related to higher laying performance of Huoyan geese, which facilitate our understanding of the reproductive biology of the goose.

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A study of association between genetic markers in candidate genes and reproductive traits in one generation of a commercial broiler breeder hen population

Cited by 62 publications

References 34 publications

Association of neuropeptide Y and gonadotrophin-releasing hormone receptor gene SNPs with breeding value for growth and egg production traits in Mazandaran native chickens

Association of neuropeptide Y and gonadotrophin-releasing hormone receptor gene SNPs with breeding value for growth and egg production traits in Mazandaran native chickens

Identification of differentially expressed known and novel miRNAs in broodiness of goose

Differential expression profiling of hypothalamus genes in laying period and ceased period Huoyan geese

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