In view of the low control precision, low degree of intelligence, low utilization rate of soybean milk, and poor conjunctiva quality in current Yuba skin production technology, a system of multifactor control and intelligent quality detection for Yuba skin was studied and designed in this paper. The system uses LabVIEW as the upper computer and the single chip microcomputer as the lower computer. Uses programming electronic control technology to set process parameters in advance, precisely control each factor to achieve adaptive control of wind speed, concentration, liquid level, and temperature, the control error of each factor is within 1%, and the quality of Yuba skin was detected by image processing technology. The application of the system greatly improves the production efficiency and intellectualization of the production line and reduces the damage degree of Yuba skin. An orthogonal test and response surface optimization were carried out for the process parameters. The test results show that the accuracy of the test results using radial basis kernel function (RBF) can reach 92.06% when the characteristic combination mode is all the characteristics, and the optimal yield will be 48.57% and the optimal quality score is 9.20 when the export angle is 36.75°, the export diameter is 9.90 mm, the export wind speed is 1.22 m/s, the slurry concentration is 7.66%, the slurry temperature is 83.26°C, and the liquid level is 30.52 mm. Comparison between the results from the regression model validation test and those from the response surface methodology is made. The relative errors of yield and quality were 0.14% and 0.87%, which indicates that the response surface methodology can effectively optimize the process parameters of Yuba skin.